It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis, presence of phenocopies within high-risk pedigrees and genetic complexity. A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p. We carried out positional cloning and mutation screening within the refined interval, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigrees. In addition, two common missense variants in the gene are associated with the occurrence of prostate cancer. ELAC2 is a member of an uncharacterized gene family predicted to encode a metal-dependent hydrolase domain that is conserved among eukaryotes, archaebacteria and eubacteria. The gene product bears amino acid sequence similarity to two better understood protein families, namely the PSO2 (SNM1) DNA interstrand crosslink repair proteins and the 73-kD subunit of mRNA 3' end cleavage and polyadenylation specificity factor (CPSF73).

Citation for published item:fryntD tFtF nd ywersD wFF nd oothmD eFFqF nd groomD FwF nd hriverD FF nd hrinkwterD wFtF nd vorenteD xFFpF nd gorteseD vF nd ottD xF nd gollessD wF nd heferD eF nd ylorD iFxF nd uonstntopoulosD sFF nd ellenD tFF nd fldryD sF nd frnesD vF nd fuerD eFiF nd flndErwthornD tF nd floomD tFF nd frooksD eFwF nd froughD F nd geilD qF nd gouhD F nd grotonD hF nd hviesD F nd illisD F nd pogrtyD vFwFF nd posterD gF nd qlzerookD uF nd qoodwinD wF nd qreenD eF nd qunwrdhnD wFvF nd rmptonD iF nd roD sFEF nd ropkinsD eFwF nd uewleyD vF nd vwreneD tFF nd veonEvlD FqF nd veslieD F nd wilroyD F nd vewisD qF nd viskeD tF nd v¡ opezE¡ nhezD ¡ eFF nd whjnD F nd wedlingD eFwF nd wetlfeD xF nd weyerD wF nd wouldD tF nd yreshkowD hF nd y9ooleD F nd ryD wF nd ihrdsD FxF nd hnksD F nd hrpD F nd weetD FwF nd homsD eFhF nd oniniD gF nd lherD gFtF @PHISA 9he ews qlxy urvey X instrument spei(tion nd trget seletionF9D wonthly noties of the oyl estronomil oietyFD RRU @QAF ppF PVSUEPVUWF Further information on publisher's website: Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. ABSTRACTThe SAMI Galaxy Survey will observe 3400 galaxies with the Sydney-AAO Multi-object Integral-field spectrograph (SAMI) on the Anglo-Australian Telescope in a 3-yr survey which began in 2013. We present the throughput of the SAMI system, the science basis and specifications for the target selection, the survey observation plan and the combined properties of the selected galaxies. The survey includes four volume-limited galaxy samples based on cuts in a proxy for stellar mass, along with low-stellar-mass dwarf galaxies all selected from the Galaxy And Mass Assembly (GAMA) survey. The GAMA regions were selected because of the vast array of ancillary data available, including ultraviolet through to radio bands. These fields are on the celestial equator at 9, 12 and 14.5 h, and cover a total of 144 deg 2 (in GAMA-I). Higher density environments are also included with the addition of eight clusters. The clusters have spectroscopy from 2-degree Field Galaxy Redshift Survey (2dFGRS) and Sloan Digital Sky Survey (SDSS) and photometry in regions covered by the SDSS and/or VLT Survey Telescope/ATLAS. The aim is to cover a broad range in stellar mass and environment, and therefore the primary survey targets cover redshifts 0.004 < z < 0.095, magnitudes r pet < 19.4, stellar masses 10 7 -10 12 M , and environments from isolated field galaxies through groups to clusters of ∼10 15 M .

We demonstrate a novel technology that combines the power of the multi‐object spectrograph with the spatial multiplex advantage of an integral field spectrograph (IFS). The Sydney‐AAO (Australian Astronomical Observatory) Multi‐object IFS (SAMI) is a prototype wide‐field system at the Anglo‐Australian Telescope (AAT) that allows 13 imaging fibre bundles (‘hexabundles’) to be deployed over a 1‐degree diameter field of view. Each hexabundle comprises 61 lightly fused multi‐mode fibres with reduced cladding and yields a 75 per cent filling factor. Each fibre core diameter subtends 1.6 arcsec on the sky and each hexabundle has a field of view of 15 arcsec diameter. The fibres are fed to the flexible AAOmega double‐beam spectrograph, which can be used at a range of spectral resolutions (R=λ/δλ≈ 1700–13 000) over the optical spectrum (3700–9500 Å). We present the first spectroscopic results obtained with SAMI for a sample of galaxies at z≈ 0.05. We discuss the prospects of implementing hexabundles at a much higher multiplex over wider fields of view in order to carry out spatially resolved spectroscopic surveys of 104–105 galaxies.