The Mediterranean-style diet has been associated with a reduced risk of cardiovascular events as well as all-cause mortality among individuals with and without cardiovascular diseases (CVD). 1,2 Those adopting the Mediterraneanstyle diet have been shown to have a lower blood pressure (BP), oxidized low-density lipoprotein, inflammatory marker concentration, and carotid intima-media thickness as well as better endothelial function. 3-6 Recently, outpatient clinic visit-to-visit blood pressure variability (BPV) has been identified as a novel risk factor for the development of cardiovascular and cerebrovascular diseases. 7,8 An elevated visit-to-visit BPV also significantly predicts all-cause and cardiovascular mortality, independent of average BP control. 9,10 Factors that have been noted to be associated with an increased visit-to-visit BPV include an increased arterial stiffness, poor compliance or improper titration of anti-hypertensive medications, as well as seasonal variations in BP. 11,12 Nevertheless, the influence of various dietary patterns, in particular the Mediterranean-style diet, on BPV has not been studied previously. In this study, we sought to investigate whether a Mediterranean-style diet among patients with coronary artery disease (CAD) is associated with a reduced BPV as well as the subsequent risk of major adverse cardiovascular events (MACEs) and all-cause mortality. Methods subjects The study population comprised of consecutive patients with known history of stable CAD currently followed-up in

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Adult female rats were treated intraperitoneally with 8 mg/kg of cis-dichlorodiammineplatinum(II). At various times after treatment 1, 3, 5, 8, 12 days replicate animals were killed and liver and kidney cytosols examined for activity of glutathione-dependent transferase activities and levels of glutathione. Hepatic levels of glutathione were depressed by 13-28% at 1, 3, 5 days after dosing. Renal levels of glutathione were increased by 3-5 fold at 8 and 12 days after drug administration. Renal levels of glutathione were decreased at nearly all times studied with a nadir at 5 days. Activity of glutathione s-acryl transferase was increased and S-epoxidetransferase was decreased at 5, 8, 12 days after dosing. When cisplatinum was added to incubation mixtures in vitro, no changes in enzyme activities were observed. When cisplatin and reduced glutathione were determined chromatographically in tissue cytosols from treated rats, 30% of the recovered platinum was associated with glutathione. In tissue cytosols, greater than 95% of the total platinum content was retained in the supernatant when protein was precipitated with trichloroacetic acid, while only 3-5% of the protein was retained.