Inferior vena cava (IVC) variations signify predisposition to deep vein thrombosis and may complicate retroperitoneal surgeries including abdominal aortic surgery and nephrectomy. Failure to recognize such variations may predispose the patient to life‐threatening complications. Despite their clinical significance, few studies have detailed variations from direct observation. This study assessed 36 cadavers for variations of the IVC and left renal vein. Prevalence was determined for the following variations: double IVC, isolated left IVC, retroaortic left renal vein, and circumaortic renal vein. Two of the 36 cadavers (5.6%) were variant. The variations included a double IVC (1:36; 2.8%) and a retroaortic left renal vein (1:35; 2.9%). There were no occurrences of an isolated left IVC or a circumaortic renal vein (0:36; 0% and 0:35; 0%, respectively). Further, the double IVC and the retroaortic left renal vein were accompanied by regional pathologies—both having kidney pathology and one with an abdominal aortic aneurysm. The results of this study suggest that, IVC variations are rare and, when an IVC variation is discovered, there is typically an attending urinary system pathology.Support or Funding InformationWest Virginia University, West Liberty University, NASA West Virginia Space Grant Consortium and West Virginia Research Challenge FundThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.

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Arterial variations within the Circle of Willis, especially hypoplastic arteries, are linked to intracranial aneurysm, atherosclerosis, and stroke; therefore, the study of Circle of Willis variants are of clinical importance. In a sample of 116 cadavers, the arteries comprising the Circle of Willis were directly observed and assessed for hypoplasia, hyperplasia, aplasia, duplication, triplication, and plexiform structure. A total of 53 different arterial patterns of the Circle of Willis were identified. The most common vascular pattern was one with no noteworthy variation of the arteries, which occurred in 34.48% (40:116) of the sample. The second most common pattern was a right hyperplastic posterior communicating artery, with concomitant right hypoplastic P1 and right hyperplastic P2 vessels which occurred in 3.45% (4:116) of cadavers. The most common variation of an individual artery, regardless of concomitant variations, was a hyperplastic right posterior communicating artery, which occurred in 19.8% (23:116) of the sample. Similarly, a right hyperplastic P2, right hyperplastic posterior communicating artery, left hypoplastic P1, and left hyperplastic posterior communicating artery each occurred in 18.1% (21:116) of cadavers. A duplicated anterior communicating artery was observed in 12.9% (15:116) of cadavers. Aplasia was only observed in the posterior communicating artery (left‐sided: 7.8%; 9:116, right‐sided: 6.0%; 7:116). The results of this study provide a clearer understanding of the variant vascular patterns of the Circle of Willis that create predisposition for aneurysm, atherosclerosis, and stroke.Support or Funding InformationWest Virginia University, Oman Medical College and West Liberty UniversityThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.