Aims of the Study: To identify plant species traditionally used to treat anemia in Yakoma territory and to evaluate their chemical composition. Place and Duration: Yakoma Territory (survey) and University of Kinshasa (Phytochemical study), from August and October 2019. Methods: Ethnobotanical survey according to the "snowball" sampling technique among traditional healers (based on the free consent of the respondents), chemical analyses of plant materials (chemical screening, TLC, phytomarkers content, minerals composition) according to standard methods. ED-XRF was used for mineral analysis. Microsoft Excel version 2010, Origin version 8.5 Pro and IBM SPSS statistics version 20 software packages were used for data processing and analysis. Results and Discussion: The survey showed that 18 plant species are traditionally used by Ngbandi traditional healers to treat anemia in Yakoma territory. They belong to 16 families and 17 genera. The most used organs are the leaves (68.4%) and the roots (10.5%). Decoction and infusion are the most used mode of preparation (33.3% each), followed by cooking (22.2%) and maceration (11.1%). The oral route (77.8%) is the most used mode of administration followed by the enema (16.7%) and the anal route (5.6%). Morphological types consist of herbs and trees                  (33.3% each) and shrubs and lianas (16.7% each). The biotope types consist of forest                         plants (44.4%), cultivated plants/Crops (38.9%), marshy ground plants (11.1%) and ruderal plants (5.6%). These plants belonging to five biological types: erected therophytes (44.4%), mesophanerophytes (27.8%), microphanerophytes and climbing phanerophytes (11.1% each) and lianescent phanerophytes (5.56%). These anti-anemic plant species are mostly Pantropical and Afro-tropical (39% of species each) followed by Guineo-Congolese (17% of species) and American (5%). Chemical analysis revealed the presence of alkaloids, anthocyanins, flavonoids, anthraquinones and terpenoids and various minerals including iron, zinc, copper, calcium, magnesium and manganese. Conclusion: In the current state of knowledge, the survey of anemic plants from this part of the Democratic Republic of the Congo is reported for the first time.