The study aims to prepare a smart copolymeric for controlled delivery of Galantamine hydrobromide. The synthesis of the hydrogel was executed through free radical polymerization using HPMC (Hydroxypropyl methylcellulose) and pectin as polymers and acrylic acid as monomer. Cross-linking was performed by methylene bisacrylamide (MBA). HPMC-pectin-co-acrylic acid hydrogel was loaded with Galantamine hydrobromide (antidementia drug) as a model drug for treatment of Alzheimer based dementia. Formulated hydrogels (SN1–SN9) were characterized for Fourier transform-infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, X-ray diffraction, and energy dispersive X-ray. Drug loading efficiency, gel fraction, measurements of porosity, and tensile strength were reported. Swelling and release studies were performed at pH 1.2 and 7.4. Drug liberation mechanism was evaluated by applying different release kinetic models. Galantamine hydrobromide was released from prepared hydrogels by Fickian release mechanism. Swelling, gel fraction, porosity, and drug release percentages were found to be dependent on hydroxypropyl methylcellulose, pectin, acrylic acid, and methylene bisacrylamide concentrations. By increasing HPMC amount, swelling was increased from 76.7% to 95.9%. Toxicity studies were conducted on albino male rabbits for a period of 14 days. Hematological and histopathological studies were carried out to evaluate safety level of hydrogel. Successfully prepared HPMC-pectin-co-acrylic acid hydrogel showed good swelling and release kinetics, which may help greatly in providing controlled release drug effect leading to enhanced patient compliance for dementia patients.

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In the developing world, the energy needs of the household sector have grown manifold, due to rapid urbanization and the introduction of affordable technology. However, constraints in the power supply and underutilization of renewable resources, coupled with inefficient fuel use and obsolete technology, have increased the average energy usage cost and emissions. Hence, the current study provides a long-term sustainable energy management plan for the urban household, in terms of energy savings, social cost, and greenhouse gas (GHG) mitigation. To address energy security and climate change challenges, a demand-side management scenario (DSM) is proposed through integration of efficient policies and nationally determined contributions. On the basis of policy analysis and energy consumption patterns, macro-economic modeling was carried out for the period 2011–2050, using the Long-range Energy Alternative Planning (LEAP) modeling tool. Results show that the “efficient water heating” scenario offers the maximum energy-saving potential (up to 270 M.TOE) whereas “efficient space cooling” is the lowest-cost scenario. To achieve the best-fit mitigation scenario (MIT), targets for renewable energy supply were also incorporated. Findings were weighed against the reference scenario (REF), which reveals a huge GHG reduction under the DSM. Moreover, the cost required to implement MIT is estimated to be 3.4 US $/tonne of carbon dioxide-equivalent, less than the REF.

The linkage between renewable energy resources and environmental influences on economic growth among selected Asian economies play a vital role in sustainable economic development. This study encompasses the panel data sets for eight selected Asian countries, and the period starts from 1990 to 2018. This research relies on the panel vector error correction model (PVECM) for data estimation. The overall findings indicate that biomass, geothermal, and wind power sources of energy have a positive and significant impact on the economic advancement of Asian economies. Besides that, as opposed to the other two renewable energy sources, windpower has a greater impact on economic development. Furthermore, the empirical findings of current research have significant implications towards selected Asian countries' energy policy related to both private and public sector enterprises as it helps in identifying the industrial sectors which have greater contribution towards the economy and their energy requirements in long term.

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