This article critically reviews published literature on the relationship between socioeconomic inequalities and health outcomes in Pakistan. Studies are systematically assessed in terms to find the relationship between the social, economic, political and biological determinants to health. The studies shown that the genetical abnormalities, malnutrition and terrorism have significantly affected the quality of life. Moreover, international relations and the national policies have adversely affected the health outcome in the masses of population. Among the socio-economic determinants social exclusion and discrimination, being woman, health compliance, economic polarization in the society, education level, unemployment and work jeopardizes derives the inequality in health of the population which eventually has the implications on the poor economy of the country.