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Objective: To find out the risk factors associated with HCV disease and evaluatethe association of risk factors of HCV disease patient’s in the population of Multan District. StudyDesign: Experimental study. Setting: Nishter Hospital of Multan District. Period: 1st January2011 to 1st April 2012. Methods: 540 patients with ages 11 to 90 years old of both sexes wereincluded in this study. All those who were surviving with HCV disease were studied with theirassociated risk factors such as age, family history; barber/parlor services, blood group types,drug use and weight loss were collected. For the data analysis, descriptive and Chi-squareanalysis are used to determine the association between risk factors and HCV. Results: Resultsshows that out of 540 patients surviving with HCV, out of which 48% are female and 52% aremales. The mean age for male and female was 37 ± 12.62 and 34 ± 11.22 respectively. Resultsshowing that blood groups types and age of the patients were significantly related to the HCVsurvival status at 5% level of significance. The study shows that HCV patients with blood group“O’ patients are maximum as compared to other groups. Conclusion: HCV is more commonin males as compare to female. Persons who are above 30 years old were more affected withHCV disease. Age and blood group types are the most significant factors in the patients whoare surviving with HCV disease.