The presence and accumulation of antibiotics in the water environment has become emerging contaminants of concern causing disruption of ecosystems worldwide. We describe here the seasonal variation and the occurrence of antibiotic residues in Fez city surface water (Morocco). During one year between February 2014 and January 2015, 8 surface water samples were collected monthly. Quantification of the 7 antibiotics was performed by on-line Solid Phase Extraction (SPE) liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 96 surface water samples were investigated and the results revealed that 100% of the sites were contaminated by at least one antibiotic. Amoxicillin had the highest concentration with maximum concentration (4107 ng L 1), followed by ciprofloxacin (1058 ng L 1) and sulfamethoxazole was the most widely detected (93%). Seasonal variation showed that the concentration of antibiotics was higher in winter for trimethoprim (96 ng L 1), ciprofloxacin (438 ng L 1) and in summer for amoxicillin (1113 ng L 1), sulfamethoxazole (162 ng L 1) and erythromycin (47 ng L 1). The results from this research show that antibiotics are frequent contaminants in Fez city surface water. This is the first attempt to assess the occurrence of these 7 pharmaceutical residues in water samples in Fez Morocco.

Les tumeurs de la paroi thoracique peuvent laisser de gros défects dans la paroi thoracique après résection tumorale. Cet article vise une mise au point sur le processus de conception et de fabrication personnalisé pour réparation des défauts osseux de la paroi thoracique après résection tumorale, en utilisant l'impression tridimensionnelle (3D). En effet le modèle 3D facilite la planification préopératoire et la modélisation d’un implant sur mesure à partir des images DICOM.

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Background: Low confidence in the safety of COVID-19 vaccines was found to be a key promoter of vaccine reluctance especially among youth. Furthermore, young adults are an important demographic for building herd immunity through vaccination. As a result, their reactions to getting COVID-19 vaccines are crucial in our fight against SARS-CoV-2 Materials and Methods: A cross-sectional survey-based study to assess the COVID-19 vaccines' short-term AEFIs among Moroccan medical and pharmacy students. The validated questionnaire was delivered in a digital form to explore the side effects (SE) they encountered after the first or the second dose of one of three vaccines namely: AstraZeneca Vaxzevria, PfizerBioNTeck, and SinoPharm vaccines. Results: There were 510 students in total who took part. After the first and second doses, approximately 72 percent and 78 percent of subjects, respectively, reported no SE. The remainder had localized injection site side effects (26 %). Fatigue (21 %), fever (19 %), headache (17 %), and myalgia (16 %) were the most common systemic adverse effects after the first dose. There were no serious SEs reported. Conclusion: The majority of the reported AEFIs in our data were mild to moderate in intensity and lasted only one or two days. COVID-19 vaccinations are highly likely safe for young adults, according to the findings of this study