A novel Wells-Dawson heteropolyacid-based magnetic Inorganic-organic nanohybrid, Fe 3 O 4 @SiO 2 @ADMPT/H 6 P 2 W 18 O 62 , was fabricated and used as a green, efficient, eco-friendly, and highly recyclable catalyst for the one-pot and multi-component synthesis of 1,4-Dihydopyridine (1,4-DHP) derivatives from the reaction of various aromatic aldehydes with ethyl acetoacetate and ammonium acetate with good to excellent yields and in a short span of time. The nanohybrid catalyst was prepared by the chemical anchoring of Wells-Dawson heteropolyacid H 6 P 2 W 18 O 62 onto the surface of functionalized Fe 3 O 4 nanoparticles with 2,4-bis(3,5dimethylpyrazol)-triazine (ADMPT) linker. These nanocatalysts were identified by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), infrared spectroscopy (IR) and vibrating sample magnetometer (VSM). This protocol is developed as a safe, cost-effective and convenient alternate method for the synthesis of 1,4-DHP derivatives utilizing an eco-friendly, and a highly reusable catalyst.

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