The epoxidation property of an asymmetric iron complex has been experimentally and theoretically verified. This catalyst further conjugated with dopamine modified Fe3O4 to obtain magnetically separable nano-catalyst.

We studied the effect of oral ascorbic acid treatment on nickel sulfate-induced lipid peroxidation in the liver of Wistar strain male albino rats. Lipid peroxide and glutathione levels and the activities of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were estimated in liver. Nickel sulfate administration significantly increased the level of lipid peroxides and decreased glutathione, SOD, CAT, and GSH-Px activities in liver. The simultaneous administration of ascorbic acid with nickel sulfate resulted in a remarkable improvement of lipid peroxide, glutathione, SOD, CAT, and GSH-Px status in liver in comparison with rats treated with nickel alone. Nickel sulfate has an adverse effect on hepatic lipid peroxidation in animals, but simultaneous treatment with ascorbic acid offers a relative protection against nickel-induced hepatotoxicity.

The phosphatase and anti-cancer activities of three novel acyl hydrazone based zinc(ii) Schiff base complexes have been unveiled.

A tridentate N,N,O donor ligand 2,4-dichloro-2-[(2-piperazine-4-yl-ethylimino)-methyl]-phenol (HL) was designed, and eight new Zn and Cd complexes, namely, [Zn(LH)(SCN)] (1), [Zn(LH)(N)] (2), [Zn(LH)(NO)] (3), [Zn(LH)(dca)(OAc)] (4), [Cd(LH)(SCN)] (5), [Cd(LH)(N)] (6), [Cd(LH)(NO)] (7), and [Cd(LH)(dca)(OAc)] (8) [where dca = dicyanamide anion] were synthesized. Five of them (1, 2, 4, 5, 7) were structurally characterized through single-crystal X-ray diffraction analysis. H-Bonding interactions are found to be the major stabilizing factor for crystallization in the solid state. Experimental and computational studies were performed in cooperation to provide a rationalization of the photoluminescence properties of those complexes. The quantum yields are anion-dependent, with enhanced efficiencies in the following order: LH < Cd-SCN(5) < Cd-dca(8) < Cd-N(6) < Cd-NO(7) < Zn-dca(4) < Zn-N(2) < ZnNO(3) < ZnSCN(1). By using quantum chemical calculations we rationalized the above trends. Moreover, the diverse lifetimes observed for those eight complexes were also quantitatively explained by considering the subtle competition between different photo-deactivation pathways.

Three new mononuclear manganese(ii) complexes, namely [Mn(HL)2]·2ClO4 (1), [Mn(HL)(N(CN)2)(H2O)2]·ClO4 (2) and [Mn(HL)(SCN)2] (3) [LH = 4-tert-butyl-2,6-bis-[(2-pyridin-2-yl-ethylimino)-methyl]-phenol], have been synthesized and structurally characterized. An "end-off" compartmental ligand (LH) possesses two symmetrical compartments with N2O binding sites but accommodates only one manganese atom instead of two due to the protonation of the imine nitrogen of one compartment. Although all three complexes are mononuclear, complex 1 is unique as it has a 1 : 2 metal to ligand stoichiometry. The catalytic promiscuity of complexes 1-3 in terms of two different bio-relevant catalytic activities namely catecholase and phenoxazinone synthase has been thoroughly investigated. EPR and cyclic voltametric studies reveal that radical formation rather than metal centered redox participation is responsible for their catecholase-like and phenoxazinone synthase-like catalytic activity. A computational approach suggests that imine bond bound radical generation rather than phenoxo radical formation is most likely responsible for the oxidizing properties of the complexes.