Summary Mango by‐products are considered cheap sources of valuable foods and nutraceutical ingredients. In this work, antioxidant capacity (AOX), and potential absorption ability (PAA) of extractable polyphenols (EP) from mango by‐product snacks (MB‐S) were evaluated at different stages of in vitro gastrointestinal digestion. A wheat and oat‐based control snack and three MB‐S formulations (F1, F2 and F3) were prepared. Mango by‐products were added at the expense of wheat in MB‐S (paste‐peel‐seed): F1 (70‐30‐0), F2 (70‐15‐15), F3 (70‐7.5‐22.5). The highest release of polyphenols was observed after the gastric digestion. In the intestinal stage, MB‐SF1 was the snack with the highest EP content (23.39 mg GAE/g db), two times greater than the control. Gallic acid and mangiferin were the main polyphenols identified in MB‐S. The incorporation of mango seed in the MB‐S reduced the polyphenols PAA by 10.29%. However, compared with the control snack, consumption of 30 g MB‐SF1 provided additional 45 mg polyphenols.

:: Lupeol (LP) and Mangiferin (MG) have beneficial effects on health, however, their pharmacokinetic properties can affect their bioavailability by oral administration, therefore, their incorporation in a hybrid matrix of ZnO and PLGA could contribute as a vehicle to improve bioavailability. Methods: Therefore, the objective of this study was to develop this matrix and evaluate its optical and bioactive properties obtained by the solvent emulsion and evaporation method, which were subjected to processes to evaluate their bioactivity as the effect of topoisomerase. Results: Functionalized treatment number 15 (TF15) showed the best results in studies of controlled release and encapsulation efficiency of lupeol (LP) and mangiferin (MG) (60.01 ± 1.24% and 57.71 ± 1.94%), the best treatment showed behaviors as a topoisomerase II inhibitor (18.60 ± 1.55). The nanoparticles developed in this study did not show a cytotoxic effect on BEAS-2B, while for HepG2 it showed a decrease in viability (IC50 1549.96 ± 174.62 µg/mL). On the other hand, although the hemolytic activity is not shown at 1 h of exposure, morphological alterations caused by TF15 are observed at concentrations of 2500 and 1250 µg/mL. Conclusion: In this context, the TF15 treatment shown by maintain its biological activity, does not present cytotoxicity for healthy cells, and decreases the growth of cancer cells.

The objective was to study the behavior of the respiration rate (RR) of guamara and cocuixtle fruits during storage, the effect or the maturity stage (green maturity and consumption maturity) of these fruits on physicochemical parameters and specific proteolytic activity, as well as the antibacterial effect of the prepurified proteases of these fruits. The guamara and cocuixtle fruits presented a RR of 15 mL CO2/kg·h and 10 mL CO2/kg·h, respectively; and because the ethylene production was not detected in any of the species, it was concluded that both fruits are of the non-climacteric type. The cocuixtle fruits presented the highest specific enzymatic activity in the state of green maturity and the guamara fruits in the state of consumption maturity, with 18.99 and 53.88 U/mg of protein, respectively. Likewise, pre-purified proteases from both fruits showed antibacterial activity against E. coli and S. aureus. It is concluded that ripened guamara fruits and green cocuixtle fruits can be an important source of proteases for the food industry and they can be used against pathogens.