Background: Overweight and type of II diabetes is emerging as important disease and the prevalence of these diseases is also increasing signicantly. Studies had proposed that irisin is having a role to play in pathophysiology of obesity and other metabolic diseases. The patients who are having type 2 diabetes are found to have higher irisin levels. The study on the association of irisin and hs-CRP with obesity and type 2 diabetes is increasing. Aim: The aim of the present study is to identify the role of irisin and HS-CRP in obesity and type II diabetes mellitus. Material and Methods: This was a community based cross-sectional study which is conducted on the medical OPD visitors of a tertiary care centre. For conducting this study 50 participants ageing between 10-50 years were selected and both male and female participants were included in this research study. In this study 25 patients belong to the case group and 25 patients were of the control group. Results: In the present study the mean of the HS-CRP was found to be 1.45±0.56 for case group and for the control group it was found to be 0.83±0.49. In the present study the mean irisin value for the case group was found to be 8.27±3.21 and for the control group it was found to be 7.47±2.54. Conclusion: In the current study it was found that the hs-CRP and the irisin level of the patients with type 2 diabetes and obesity are higher as compared with the normal individuals. It can be said that both the hs-CRP and the irisin level are positively associated with the obesity and type II diabetes mellitus.