PurposeSince the role of short- and long-term intraocular pressure (IOP) fluctuation as a predictor of glaucoma progression is still controversial, the purpose of this study was to investigate the role of IOP fluctuation in a non-selected patient cohort.Materials and methodsTwo-hundred and forty eyes of 120 glaucoma patients (51% female) with a mean age of 64.5 years were included. Inclusion criteria were at least a visual field (VF) and a 48-hour diurnal phasing of IOP including nocturnal measurement. Glaucoma progression was defined as – if available – confirmed progression of reproducible VF defects in at least three VF examinations or increase of cup area on optic nerve imaging (Heidelberg Retina Tomograph [HRT]) with at least two images after baseline. If results were stable or less than previously mentioned VF or HRT examinations were available, it was classified as “no progression”.ResultsGlaucoma progression was seen in seven of 240 eyes in the VF analysis and ten of 240 eyes on HRT. Of all 240 eyes, 92 and 41 eyes fulfilled the criteria to be included for progression evaluation on VF and HRT analysis, respectively. Mean time to progression ± standard error was 3.6±0.2 years on VF and 4.5±0.3 years on HRT. Univariate and multivariate Cox regression analyses revealed short-term IOP fluctuation (P<0.0001) and maximum IOP (P<0.001) as risk factors for glaucoma progression on VF. There was no significant influence of demographic characteristics, ocular or general health on glaucoma progression.ConclusionShort-term IOP fluctuation was associated with the progression of glaucoma in this non-selected cohort of glaucoma patients receiving phasing of IOP.

Today's communication systems typically use high resolution analog-to-digital converters (ADCs). However, considering future communication systems with data rates in the order of 100 Gbit/s the ADC power consumption becomes a major factor due to the high sampling rates. A promising alternative are receivers based on 1-bit quantization and oversampling w.r.t. the signal bandwidth. Such an approach requires a redesign of modulation, receiver synchronization, and demapping. A zero crossing modulation is a natural choice as the information needs to be carried in the zero crossing time instants. The present paper provides an overview on zero crossing modulation, achievable rates, sequence mapping and demapping, 1-bit based channel parameter estimation, and continuous phase modulation as an alternative zero crossing modulation scheme.

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