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3.1 INTRODUCTION 3.2 H-BEST 3.3 EXPERIMENTAL MODELING APPROACH 3.4 RESULTS 51 3.5 CONCLUSION 3.6 REFERENCES CHAPTER 4. ACCURATE PREDICTIVE MODELING WITH OPTIMAL EXPERIMENTAL DESIGN OF THE HUMAN THERMOREGULATORYSYSTEM ABSTRACT 58 4.1 INTRODUCTION 4.2 EXACT SOLUTION TO A HAMMERSTEIN SYSTEM 61 4.3 EXPERIMENTAL MODELING APPROACH 4.3.1 H-BEST Algorithm 4.3.2 Optimizing the number of experimental trials 68 4.3.3 Optimizing the time length of experiments 4.4 RESULT 78 4.5 CONCLUSION 83 4. 6 REFERENCES 8