A family of 7-aryl-3-methylpyrazolo[1,5-a]pyrimidines have been identified as strategic compounds for optical applications by a comprehensive theoretical-experimental study.
An operably simple microwave-assisted BF3-mediated
acetylation
reaction of pyrazolo[1,5-a]pyrimidines and a plausible
mechanism based on density functional theory (DFT) theoretical calculations
for this transformation are reported. Remarkably, and to the best
of our knowledge, this is the first example of the direct acetylation
for the functional pyrazolo[1,5-a]pyrimidine (PP)
core. The synthesis of this essential building block is reported in
high yields using mild reaction conditions, inexpensive reagents,
and even substrates with electron-deficient or highly hindered groups.
In addition, one of the new methyl ketones was successfully used as
a substrate for producing novel and valuable bis-electrophilic compounds
with yields of up to 90%. Notably, the discovered acetylation method
was successfully applied in other π-excedent (N-hetero)aromatic substrates.
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