Background: The intensity of the inflammation induced by Helicobacter pylori colonization is associated with the development of distal gastric cancer (GC). The host response to H. pylori has been related to genetic polymorphisms that influence both innate and adaptive immune responses.

The purpose of this study was to assess the role of Helicobacter pylori and several genetic polymorphisms in relation to inflammatory bowel disease (IBD). We studied 44 unrelated patients with IBD and 75 subjects with no history of IBD as controls. Using pyrosequencing technology, we identified gene polymorphisms in IL-10, TNF-A, ILB-31, and TLR4. H. pylori status was determined by serology. Individuals homozygous for IL10-592 A or IL10-1082 A genotypes show significantly lower occurrence of IBD (P=0.03 and P<0.01, respectively). Individuals heterozygous at IL10-1082 have significantly increased occurrence of IBD, both ulcerative colitis and Crohn's disease (P<0.01). There was no difference in the prevalence of H. pylori infection between cases and controls. This study provides evidence that variation in IL10 is correlated with IBD occurrence in this Mexican population.

This is the first report on prevalence of H. pylori in pediatric patients with RAP from the northeastern region of Mexico. The prevalence of H. pylori was low compared with the adult population in the same geographic region. Serology had the best diagnostic utility.

Objective: Human immune recognition of self and foreign is partially controlled by a set of genes in the human leukocyte antigen complex (HLA). HLA is the most polymorphic region in the human genome, and it is used to assure compatibility between donor and recipient for hematopoietic stem cell transplantation. There are six "classical" HLA genes encoding highly polymorphic loci: HLA-A, B, and C (Class I major histocompatibility complex), and HLA DR, DQ, and DP (Class II). This study aims to quantify the frequency of HLA A, B, C, DRB1, and DQB1 alleles taken in a transplant center in the northeastern part of Mexico. Methods: Descriptive and retrospective data of HLA typing by polymerase chain reactions-SSP for class I and II HLA in our Institution were analyzed. Tests for HLA-A, B, C, DRB1, and DQB1 were performed in 1614 patients. The number of haplotypes found was 726. Results: The most common combinations were A*02, B*35, C*04, DRB1*08, and DQB1*04, which were observed 38 times (5.2%). Conclusion: The most frequent HLA alleles were HLA-A2 and HLA-DQ 03, respectively, with a frequency of 0.2961 and 0.2758.

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