The accuracy of 476 oxygen flowmeters was investigated using a thermal mass flowmeter in eight hospitals in France and Belgium. Different oxygen flow rates (2 to 15 l/min) were evaluated at the patient's bed. When the sample was considered as a whole, the accuracy of delivered flow was acceptable but precision was poor. The variability of the delivered flow between devices was greater when a low flow rate was required. Compensated-pressure oxygen flowmeters for these low rates were more accurate than their non-compensated counterparts. This study emphasizes the need to individually adapt the oxygen flow rate each time a patient has to move from one flowmeter to another.

Background: Endothelial cell dysfunction, by promoting fibrin deposition, has been implicated in the development of multiple organ failure. Altered fibrinolysis during inflammation may participate in microvascular alterations. We sought to determine whether plasma fibrinolysis was related to the severity of organ dysfunction and/or to the levels of von Willebrand factor (vWF antigen), as a marker of endothelium dysfunction, in critically ill patients.

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