Immunogenic proteins from nonliving promastigote polyvalent Leishmania vaccine against American tegumentary leishmaniasis (Leishvacin  ), produced by Biobrás (Biochemistry of Brazil ), Montes Claros, State of Minas Gerais, Brazil, were identified and purified by polyacrylamide electrophoresis gel and electroelution. C57BL/10 mice were vaccinated with proteins with estimated molecular weights of 42, 46, 63, 66, 73, 87, 97, and 160kDa in three doses of 30µg of each protein at 15-day intervals combined with 250µg of Corynebacterium parvum followed by a challenge infection with 10 5 infective promastigotes from Leishmania (Leishmania) amazonensis. The ability of these proteins to induce immune response and protection was analyzed. No statistical difference was observed in the level of IFN-γ induced by proteins in vaccinated groups in comparison with control groups. Six months after challenge infection, protection levels of 28.57; 42.86; 57.14; 42.86; 42.86, 57.14; 42.86 and 57.14% were demonstrated for each purified protein.

Anatomia óssea e muscular do antebraço e mão de Chrysocyon brachyurus (carnivora, canidae)* Bone and muscular anatomy of the antibone and hand of Chrysocyon brachyurus (carnivora, canidae

Objective: to evaluate the prevalence and risk factors associated with self-medication in pre- and postoperative conditions in tooth extraction. Method: interviews were conducted with 40 patients from a university dental clinic between September and October 2018, addressing socio-demographic variables, medication use and comorbidities. Chi-square test with significance level of p<0.05 was applied. Results: the prevalence of preoperative self-medication was 52.5% and 15% after surgery, of which 5% self-medicated before and after the procedure (p<0.001). It was found that 68.4% of the respondents who self-medicated preoperatively were women, and postoperatively, 75% were men (p<0.05). The most taken drugs before surgery were analgesic (p<0.05) and after were anti-inflammatory (p>0.05). Conclusion: tooth extraction was a protective factor for self-medication. This behavior varied between sexes, requiring specific prescription protocols for men and women in dental extraction.

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