Background Coronary angiography is the gold standard for the diagnosis of coronary artery disease. This intervention is nevertheless a source of anxiety for the patient both by its discomfort and by the consequences linked to the discovery of potential diseases. Objectives The aim of this study was to determine the effectiveness of hypnosis in reducing anxiety in patients undergoing coronary angiography. Methods One hundred sixty-nine patients with planned coronary angiography and no history of coronary angiography were randomized to a hypnosis or control group. Patients in the hypnosis group underwent a hypnosis session with self-hypnosis posthypnotic suggestions, while those in the control group had a conversational interview with the hypnotherapist. The primary endpoint was pre-exam anxiety level assessed by the Spielberger State-Trait Anxiety Inventory (STAI-Y A). Results Performing a hypnosis session did not result in a significant decrease in anxiety before the intervention. Age, high trait anxiety, high state anxiety the day before, and belief that hypnosis works in general were associated with increased anxiety before the procedure. No adverse events were reported after hypnosis. There was no statistically significant difference between the 2 groups for the occurrence of complications of the intervention. Conclusion In this study, performing a hypnosis session before coronary angiography did not reduce the state of anxiety measured just before the intervention. In all cases, the hypnotic experience appears to be positive for the patient, encouraging further research efforts. Trial registration The research protocol has been registered on the ClinicalTrials.gov registry (NCT02818101; 29/06/2016) and with the ANSM (IDRCB 2016-A00205-46; 02/02/2016).

Objective This study was initiated and conducted by several laboratories, 3 of the main cosmetic ingredient suppliers and 4 brands of cosmetics in France. Its objective is to show the interest and robustness of coupling chemical and genetic analyses in the identification of plant species. In this study, the Lavandula genus was used. Methods In this study, we used two analytical methods. Chemical analysis from UHPLC (ultra‐high‐performance liquid chromatography) and genetic analysis from barcoding with genetic markers. Results Eleven lavender species were selected (botanically authenticated) and analysed. The results show that three chemical compounds (coumaric acid hexoside, ferulic acid hexoside and rosmarinic acid) and three genetic markers (RbcL, trnH‐psbA and ITS) are of interest for the differentiation of species of the genus lavandula. Conclusion The results show that the combination of complementary analytical methods is a relevant system to prove the botanical identification of lavender species. This first study, carried out on a plant of interest for cosmetics, demonstrates the need for authentication using a tool combining genetic and chemical analysis as an advance over traditional investigation methods used alone, in terms of identification and authentication reliability.

Background – Coronary angiography is the gold standard for the diagnosis of coronary artery disease. This procedure is nevertheless a source of anxiety given the inconvenience caused by its invasiveness but also due to the consequences linked to the discovery of potential diseases.Aim - The aim of this study was to determine the effectiveness of hypnosis on reducing patient anxiety prior to coronary angiography.Methods – A total of 169 patients with non-urgent indications of coronary angiography and no history of prior coronary angiography were randomized to a hypnosis or control group. Patients in the hypnosis group underwent a hypnosis session with posthypnotic suggestions in self hypnosis, while those in the control group had a conversational interview with the hypnotherapist. The primary endpoint was the level of anxiety prior to the exam assessed by the Spielberger State-Trait Anxiety Inventory (STAI-Y A).Results - Performing a hypnosis session did not translate into a significant decrease in anxiety prior to the procedure. Age, trait anxiety, state anxiety the day before and belief that hypnosis works in general were associated with anxiety prior to the procedure. There was no adverse effect secondary to hypnosis. There was no statistically significant difference between the 2 groups for the occurrence of complications due to the procedure.Conclusion - In the present study, performing a hypnosis session upstream of a coronary angiography, did not reduce the state anxiety measured immediately before the intervention. In all cases, the hypnotic experience seems to be positive for the patient, which encourages further research efforts.Trial registration - The research protocol was registered on the ClinicalTrials.gov registry (NCT02818101; 29/06/2016) and with the ANSM (IDRCB 2016-A00205-46; 02/02/2016).