The aim of this study was to analyze the relationship between satisfaction with life in general and the sociodemographic and emotional factors and components of quality of life in people with chronic kidney disease undergoing hemodialysis. A cross-sectional and correlational study was performed on a sample of 171 people with chronic kidney disease in two hemodialysis units at a Clinic in Lisbon between May and June 2015. Subjective wellbeing (personal wellbeing index) is positively related with subjective happiness, positive afect, and quality of life and is negatively associated with negative afect. Subjective happiness, negative afect, and the physical component of quality of life inluence subjective wellbeing. These conclusions can assist us in understanding that people with chronic kidney disease (CKD) encounter greater feelings of wellbeing, mainly related to pleasant afect (subjective happiness and positive afect).

Objetivo: evaluar la calidad de vida de los pacientes trasplantados de riñón que son seguidos en la consulta externa. Método: Este es un estudio transversal y correlacional. La muestra consistió en 55 pacientes que se sometieron a un trasplante de riñón en la región de Lisboa, Portugal. La recolección de datos se realizó en mayo de 2017. También se utilizaron el cuestionario WHOQOL-bref y variables sociodemográficas y clínicas. Los resultados: El valor más bajo se encuentra en el dominio físico y los valores más altos en las facetas ambientales y generales de la calidad de vida. La faceta general de la calidad de vida se asocia positivamente con el dominio físico, el dominio psicológico y el dominio ambiental. Conclusiones: El dominio físico de la calidad de vida relacionada con los pacientes trasplantados de riñón fue el más perjudicado. Se examinan las consecuencias de la práctica clínica para la enfermería.

Hydrogen sulfide is produced endogenously by a variety of enzymes involved in cysteine metabolism. Clinical data indicate that endogenous levels of hydrogen sulfide are diminished in various forms of cardiovascular diseases. The aim of the current study was to investigate the effects of hydrogen sulfide supplementation on cardiac function during reperfusion in a clinically relevant experimental model of cardiopulmonary bypass. Twelve anesthetized dogs underwent hypothermic cardiopulmonary bypass. After 60 minutes of hypothermic cardiac arrest, reperfusion was started after application of either saline vehicle (control, n = 6), or the sodium sulfide infusion (1 mg/kg/hour, n = 6). Biventricular hemodynamic variables were measured by combined pressure-volume-conductance catheters. Coronary and pulmonary blood flow, vasodilator responses to acetylcholine and sodiumnitroprusside and pulmonary function were also determined. Administration of sodium sulfide led to a significantly better recovery of left and right ventricular systolic function (P < 0.05) after 60 minutes of reperfusion. Coronary blood flow was also significantly higher in the sodium sulfide-treated group (P < 0.05). Sodium sulfide treatment improved coronary blood flow, and preserved the acetylcholine-induced increases in coronary and pulmonary blood (P < 0.05). Myocardial ATP levels were markedly improved in the sulfide-treated group. Thus, supplementation of sulfide improves the recovery of myocardial and endothelial function and energetic status after hypothermic cardiac arrest during cardiopulmonary bypass. These beneficial effects occurred without any detectable adverse hemodynamic or cardiovascular effects of sulfide at the dose used in the current study. The aim of the current study was to test potential cytoprotective and anti-inflammatory effects of the novel biological mediator hydrogen sulfide in murine models. Murine J774 macrophages were grown in culture and exposed to cytotoxic concentrations of nitrosoglutathione, or peroxynitrite (a reactive species formed from the reaction of nitric oxide and superoxide). Pretreatment of the cells with sodium sulfide (60-300 µM) reduced the loss of cell viability elicited by the nitric oxide donor compound (3 mM) or by peroxynitrite (3 mM), as measured by the MTT method. Sodium sulfide did not affect cell viability in the concentration range tested. In mice subjected to bacterial lipopolysaccharide (LPS, 5 mg/kg i.p.), treatment of the animals with sodium sulfide (0.2 mg/kg/hour for 4 hours, administered in Alzet minipumps) reduced the LPSinduced increase in plasma IL-1β and TNFα levels. These responses were attenuated when animals were pretreated with the heme oxygenase inhibitor tin-protoporphyrin IX (6 mg/kg). The current results point to the cytoprotective and anti-inflammatory effects of hydrogen sulfide, in cells exposed to nitrosative stress, and in animals subjected to endotoxemia. Introduction It has been previously shown that the two forms of acute cholecystitis, acute acalculous cholecystiti...

Objetivo: Analisar as propriedades psicométricas da versão reduzida da escala portuguesa Positive and Negative Affect Schedule em pessoas com doença renal crónica submetidas a hemodiálise. Métodos: Estudo Psicométrico. Utilizou-se uma amostra aleatória composta por 183 pessoas submetidas a hemodiálise em duas clínicas e um serviço de nefrologia na região de Lisboa, Portugal. Os dados foram recolhidos de maio a junho de 2015. Foram avaliadas as propriedades psicométricas: validade (construto, convergente e preditiva), confiabilidade (α de Cronbach) e estabilidade (teste-reteste). Resultados: A versão reduzida da escala portuguesa Positive and Negative Affect Schedule apresenta duas dimensões distintas de afeto positivo e negativo, confiáveis e estáveis, obtidas por entrevista e por questionário. Conclusões: Verificou-se que a validade e reprodutibilidade da versão reduzida da escala portuguesa Positive and Negative Affect Schedule em pessoas com doença renal crónica são consistentes com a versão original e com a versão da escala portuguesa. Palavras-Chave: Emoções; insuficiência renal crónica; estudos de validação; psicometria; enfermagem. RESUMEN Objetivo: analizar las propiedades psicométricas de la versión reducida de la escala portuguesa Positive and Negative Affect Schedule en personas con enfermedad renal crónica sometidas a hemodiálisis. Métodos: estudio psicométrico. Se utilizó una muestra aleatoria de 183 personas sometidas a hemodiálisis en dos clínicas y un servicio de nefrología en la región de Lisboa, Portugal. Los datos se recolectaron de mayo a junio de 2015. Se evaluaron las propiedades psicométricas: validez (constructo, convergente y predictivo), confiabilidad (α de Cronbach) y estabilidad (test-retest). Resultados: La versión reducida da escala portuguesa Positive and Negative Affect Schedule tiene dos dimensiones distintas de afecto positivo y negativo, siendo confiable y estable, obtenida por entrevista y cuestionario. Conclusiones: La validez y la reproducibilidad de la versión reducida de la escala portuguesa Positive and Negative Affect Schedule en personas con enfermedad renal crónica fueron consistentes con la versión original y la versión de la escala portuguesa.