Although the phospholipase C (PLC)β-1 isoform is associated with spontaneous seizure and distinctively expressed in the telencephalon, the distribution of PLCβ-1 expression in the epileptic gerbil hippocampus remains controversial. Therefore, we determined whether PLCβ-1 is associated with spontaneous seizure in an animal model of genetic epilepsy. In the present study, PLCβ-1 immunoreactivity was down-regulated in seizure-sensitive (SS) gerbils more than in seizure-resistant (SR) gerbils. The expression of PLCβ-1 within calretinin (CR)-positive neurons was rarely detected within the dentate hilar region of SS gerbils. PLCβ-1 immunoreactivity in the hippocampus was significantly elevated as compared to that in pre-seizure SS gerbil 3 h post-ictal. These findings suggest that alterations in PLCβ-1 immunoreactivity in the SS gerbil hippocampus may be closely related to the epileptic state of the gerbil brain and transiently elevated PLCβ-1 protein levels following seizure episodes. Such alterations may be compensatory responses in the SS gerbil hippocampus. [BMB reports 2011; 44(9) : 566-571]
In this study, we carried out an experimental shield TBM excavation model test using a down-scale device in soft clay, to understand tunnel-face stability properties in relation to changes in slurry pressure. We performed five tests according to tunnel depth (0.5D, 0.75D, 1.0D, 1.25D, 1.5D), and compared theoretical tunnel-face pressure with model test results. The range in theoretical tunnel-face slurry pressure (P min ≤P slurry pressure ≤P max ), which is determined by earth pressure and water level, was very similar to the model test result. This result was due to the more isotropic condition of the soft clay ground, than of rocky ground.
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