Introduction There is a high prevalence of depression in developing countries, and low mental health literacy has been hypothesized as one of the main causes of increasing rates of mental illness in a population. This study aimed to capture an image of the current attitude and perceptions towards victims of clinical depression in Pakistan and to assess the impact of those beliefs. Methods A cross-sectional study was conducted with 400 people, chosen through non-probability consecutive sampling, from Karachi, Pakistan. A questionnaire was designed to evaluate the overall perception of depression including its causes, manifestations and treatment options. Descriptive statistics were used and p-values less than 0.05 calculated using the chi-square test were considered significant. Results Most of the participants comprehended depression as a natural feeling of sadness rather than a mental disorder. The vast majority cited increased stress (72.2%) and physical/ emotional trauma (51.3%) as the main causes of depression. The most popularly associated symptoms were sadness (53.3%), irritability (53.3%), inability to perform daily tasks (52.8%), and changes in sleeping patterns (52%). Participants believed depression to be best treated by talking to someone trustworthy (59.5%), praying to God (56.5%) and consulting a psychologist/psychiatrist (52.3%). There was a significant association between the participants’ level of education and their perception of clinical depression (p=0.026). Conclusion Our study showed a skewed perception of depression with the majority only acknowledging it as a natural feeling of sadness. However, stress was seen as a major perpetrator and the importance of a good support system was acknowledged by most participants. Level of education was revealed to be the most important factor that influenced these beliefs. Effective community-based programs and policies based on these public views will help develop an accessible and autonomous support system for patients with mental illnesses.