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Baylis-Hillman adduct-derived N-cinnamylsubstituted isatin derivatives were synthesized and evaluated for their antitubercular activity on Mycobacterium tuberculosis H 37 Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (3j-l) have shown significant activity against Mycobacterium strain and the compound 3l has shown specific cytotoxic activity.

a b s t r a c tLet v be a real valuation of a field K with valuation ring R v . Let K (θ ) be a finite separable extension of K with θ integral over R v and F (x) be the minimal polynomial of θ over K . Using Newton polygons and residually transcendental prolongations of v to a simple transcendental extension K (x) of K together with liftings with respect to such prolongations, we describe a method to determine all prolongations of v to K (θ ) along with their residual degrees and ramification indices over v. The problem is classical but our approach uses new ideas. The paper gives an analogue of Ore's Theorem when the base field is an arbitrary rank-1 valued field and extends the main result of [S.D. Cohen, A. Movahhedi, A. Salinier, Factorization over local fields and the irreducibility of generalized difference polynomials, Mathematika 47 (2000) .

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