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Background: Diabetes is a pandemic causing very high morbidity and mortality due to its complications which are a result of micro and macro angiopathy. Platelets play a key role in the vascular complications. These complications are attributed to platelet activation which can be recognised by an increase in platelet volume indices (PVI) including mean platelet volume (MPV) and platelet distribution width (PDW). Platelet indices can be potentially useful surrogate markers for the early diagnosis of thromboembolic and cardiovascular complications in diabetes. Methods: This is a cross-sectional study conducted for 2 years with total 930 subjects. The patients were segregated in 03 groups on basis of HbA1C as (a) Diabetic, (b) Non-Diabetic and (c) FG. Samples for HbA1C and platelet indices were collected using EDTA (ethylene diamine tetracetic acid) as anticoagulant and were processed on autoanalysers. Results:The study revealed a stepwise increase in the PVI from non-diabetics to IFG to diabetics. MPV and PDW were increased in the IFG cases as compared to the non-diabetic and were markedly increased in the diabetic patients. MPV and PDW of diabetics, IFG and non-diabetics were 17.60±2. 04, 11.76±0.73, 9.93±0.64 and 19.17±1.48, 15.49±0.67, 10.59±0.67 respectively with a significant p value 0.00. Significant positive correlation between PVI with glycaemic levels and duration of diabetes across the groups (MPV-HbA1c r = 0.951; PDW-HbA1c r = 0.875). However, the total platelet count was found to decrease with the increasing glycaemic levels with a p value <0.001. A significant negative correlation was found between glycaemic levels and total platelet count (PC-HbA1c r = -0.164). Conclusions: This study showed that platelet morphology is altered with increasing glycaemic levels. These changes can be known by measurements of PVI which is an important simple and effortless tool can be used more extensively to predict the acute vascular events and thereby help curb morbidity and mortality.

Background: Dermatological disorders are common in all countries but the spectrum varies greatly. While skin diseases are very common among the populations in many developing countries, they have not been regarded as a significant problem, which could benefit from public health measures. Aims & Objective: To analyze the role of histopathology in making the diagnosis of skin lesion. Materials and Methods: In the period of 2009 to 2014, we retrospectively analyzed data of 112 patients. Patient's data were retrieved from the archives of the Department of Pathology, M.G.M. Medical College, Indore. Results: A total of 112 patients were included in the study, 63 cases (56%) were males and 49 cases (44%) were females. In males, the commonest lesions were granulomatous lesions (n-30, 26.80, %) followed by nonspecific dermatoses. In females, the commonest lesions were nonspecific dermatoses (n= 15, 13.6%) & granulomatous lesions (n-18, 16.4%). Conclusion: Skin diseases were more common in males than females. Granulomatous lesions were common in males than females.

Background: Ovarian tumor is the seventh most common cause of cancer related deaths in female. The aim of this study is to find the, morphological and clinicopathological correlation, gross, histological pattern, and incidence of age distribution of ovarian tumors. Materials and Methods:This retrospective and prospective study was carried out from January 2011 to December 2015. The diagnosis was confirmed by histopathological examination using hematoxylin and eosin stain. Special stains and immunohistochemistry were carried out whenever needed.Results: Out of total 158 cases, 62.65% were benign, 3.79% were borderline, and 33.55% were malignant. Histologically, surface epithelial tumors were the most common (74.06%) followed by germ cell tumours(15.82%) and sex cord-stromal tumors (10.12%).Benign tumors were mostly seen in age group of 20-40 years, borderline 21-40 years, and malignant 50-80 years. Conclusion:Tumors originating from surface epithelium are the most common and their malignant counterparts are more frequent in the elderly age group.

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