Background
Filariasis is a tropical vector-borne disease seen predominantly in endemic areas, and the most common presentation is a lymphatic disorder in the form of lymphangiectasia. This case describes the breast as one of the uncommon sites of involvement by the filarial worm.
Case presentation
We report an uncommon case of breast filariasis with chief complaints of a nodular lump in the breast.
Conclusions
As symptoms of breast filariasis can mimic breast malignancy, appropriate diagnosis using real-time ultrasound plays a crucial role to reduce psychological stress on the patient and also helps in planning treatment.
Introduction
Rosai–Dorfman disease is a rare disorder caused by benign proliferation of histiocytes and thus also called sinus histiocytosis with massive lymphadenopathy. It is typically known to involve lymph nodes but can also affect extra nodal sites with breast involvement being extremely rare. This disease is known to mimic malignancy clinically and on imaging. The final verdict is through histopathological evaluation.
Case presentation
We present a case of a 21-year-old female who presented with a palpable suspicious lump in right breast. Ultrasound, mammogram and MRI breast were done followed by fine needle aspiration, which showed lymphocytes and occasional histiocytes, which is suggestive of a lymphoid process. Surgical excision was done due to high suspicion of low-grade angiosarcoma in spite of a negative cytology. Diagnosis of Rosai–Dorfman disease was concluded after histopathological evaluation and was further confirmed by immunohistochemical staining by immunohistochemical markers S-100 and CD68.
Conclusion
Rosai–Dorfman disease can present as low-grade angiosarcoma clinically as well as on imaging. There is a need for high level of suspicion to rule out benign mimics of malignancy to avoid radical surgery. Final diagnosis is by histopathology along with immunohistochemical staining.
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