e10214th International Congress on Infectious Diseases (ICID) Abstracts demic. The last of these is called Swine flue (influenza A H1N1), which since its inception has caused great alarm, high morbidity and mortality especially in pregnant women. This is a sample of the features of the disease in Dominican Republic.Dominican Republic is a tropical country located in the Caribbean that receive substantial annual number of tourists, which makes influenza outbreaks throughout the year: both seasonal peaks in the northern and southern hemisphere.Methods: The Epidemiology National Program starts a surveillance since the epidemic arise at level 5, at epidemiological week 16.Diagnosis confirmation was made with rt-PCR for A H1N1 to all symptomatic respiratory cases.Results: Until the 40th epidemiology week, we have 2,664 suspicious cases, 997 (37%) hospitalized, 441 confirmed cases, from this 191 (45%) hospitalized, and 22 (5%) death, 76 (17%) cases were pregnant women with 16% mortality.Clinical manifestations were: fever (94%), cough (89%), nasal congestion (76%), headache (71%), muscle pain (67%), sore throat (60%), dyspnoea (45%), nausea (25%), rales (21%), vomiting (18%) and diarrhoea (11%).Pregnancy was one of the more important risk factor associated with mortality.Necropsy findings where: edema, hemorrhage and necrosis in lung tissues, frequently associate with intravascular thrombosis.High mortality was cause due a delay in search of medical attention and no suspected diagnosis from health cares personel.Conclusion: It must be increased the Primary Care Services to obtain an early diagnosis of the disease, and began the antiviral treatment in high risk populations, when this pathology is suspected, mostly in pregnant women.