Purpose: To demonstrate the effect of Cytosorb on reducing the cytokine levels seen due to cytokine storm in severe COVID 19 patients. Material & Methods: COVID 19 patients with severe HRCT scoring and on NIV/ MV were included in the study. The time points considered in our study are D0, D+1, D+3 & D+5, to look for the levels of inflammatory markers post therapy along with the outcome of patients on D+7 in terms of mortality or off NIV/ MV. Results: Statistical significance tested for the reduction in the WHO score value resulted p value of 0.85. The mean baseline value of the inflammatory markers, CRP, D-DIMER & IL 6 were 66.94, 780.67 &144.67 respectively with range 56.5-81, 331-1211 & 124-167 respectively & p values 0.60, 0.95 & 0.18 respectively. 7-day outcome of the study was 100% mortality.

Introduction: The aim of this study was to demonstrate the purpose of adding antiviral (remdesivir) to the existing steroidal (dexamethasone) therapy in treating coronavirus disease 2019 (COVID-19). Methodology: A retrospective observational case cohort study was carried out to compare the effect of dexamethasone alone and in combination with remdesivir in treating moderate and severe COVID-19 disease. The patients were divided into 2 groups: Group 1 included patients treated with dexamethasone alone, and Group 2 included patients treated with dexamethasone and remdesivir. Levels of inflammatory markers (C-reactive protein, D- dimer and lactate dehydrogenase), World Health Organization (WHO) ordinal scale scoring, symptomatic improvement in terms of fever, cough, shortness of breath, 6-minutes’ walk test and SpO2 levels on day of admission (D0), 3 days and 5 days after admission (D3 and D5), and 10 days overall outcome (determined as death, or discharge with or without Long Term Oxygenation Therapy) were collected and analyzed. Results: Addition of remdesivir to dexamethasone in treating COVID 19 did not have any additional benefits. No additional role of remdesivir is seen in combating the disease except in case of 10 days outcome. However, the better 10-day outcome associated with the use of remdesivir was thought to be due to the patients who were on mechanical ventilation in the dexamethasone treated group at the time of inclusion. Conclusions: Since a similar trend was seen in both groups, our study concluded no additional role of remdesivir in combating COVID-19.