Research aim in this article is to investigate comparative evaluation between simultaneous and isolated laparoscopic surgery of patients with cholelithiasis. Operation in laparoscopic cholecystectomy considered as a standard method of treatment with the main advantage of quick recovery. The technique is safe and frequency of conversions to open surgery is minimal. Comparative evaluation results showed that simultaneous laparoscopic surgery in choleithiasis have advantages as removal of the gallbladder and at the same time additional removal of other organs pathologies in abdominal cavity or small pelvis or retroperitoneal space with cholestycytectomy. In addition, simultaneous laparoscopic surgery is economically beneficial for patients, it is not necessary for patients to test again and duration of patients’ temporary disability can be reduced. At the same time more than two organs can be operated with reduction of the postoperative stay days of patients in the hospital.