HLA haplotypes were found to be associated with increased risk for viral infections or disease severity in various diseases, including SARS. Several genetic variants are associated with COVID-19 severity. Studies have proposed associations, based on a very small sample and a large number of tested HLA alleles, but no clear association between HLA and COVID-19 incidence or severity has been reported. We conducted a large-scale HLA analysis of Israeli individuals who tested positive for SARS-CoV-2 infection by PCR. Overall, 72,912 individuals with known HLA haplotypes were included in the study, of whom 6413 (8.8%) were found to have SARS-CoV-2 by PCR. A total of 20,937 subjects were of Ashkenazi origin (at least 2/4 grandparents). One hundred eighty-one patients (2.8% of the infected) were hospitalized due to the disease. None of the 66 most common HLA loci (within the five HLA subgroups: A, B, C, DQB1, DRB1) was found to be associated with SARS-CoV-2 infection or hospitalization in the general Israeli population. Similarly, no association was detected in the Ashkenazi Jewish subset. Moreover, no association was found between heterozygosity in any of the HLA loci and either infection or hospitalization. We conclude that HLA haplotypes are not a major risk/protecting factor among the Israeli population for SARS-CoV-2 infection or severity. Our results suggest that if any HLA association exists with the disease it is very weak, and of limited effect on the pandemic. Supplementary Information The online version contains supplementary material available at 10.1007/s10875-021-01071-x.

HLA haplotypes were found to be associated with increased risk for viral infections or disease severity in various diseases, including SARS. Several genetic variants are associated with Covid-19 severity. However, no clear association between HLA and Covid-19 incidence or severity has been reported. We conducted a large scale HLA analysis of Israeli individuals who tested positive for SARS-CoV-2 infection by PCR. Overall, 72,912 individuals with known HLA haplotypes were included in the study, of whom 6,413 (8.8%) were found to have SARS-CoV-2 by PCR. a Total of 20,937 subjects were of Ashkenazi origin (at least 2/4 grandparents). One hundred eighty-one patients (2.8% of the infected) were hospitalized due to the disease. None of the 66 most common HLA loci (within the five HLA subgroups; A, B, C, DQB1, DRB1) was found to be associated with SARS-CoV-2 infection or hospitalization. Similarly, no association was detected in the Ashkenazi Jewish subset. Moreover, no association was found between heterozygosity in any of the HLA loci and either infection or hospitalization.We conclude that HLA haplotypes are not a major risk/protecting factor among the Israeli population for SARS-CoV-2 infection or severity.

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Absorption measurements on silver bromide crystals and fibers in the infrared J. Appl. Phys. 113, 043111 (2013); 10.1063/1.4789633 Mid-infrared (λ=8.4-9.9μm) light scattering from porcine tissue Appl. Phys. Lett. 101, 093705 (2012); 10.1063/1.4748331Hot free-electron absorption in nonparabolic III-V semiconductors at mid-infrared wavelengths Absorption spectrum of silver bromide crystals and fibers in the 9-11 μm wavelength rangeThe attenuation and the absorption of silver halide crystal and fibers in the mid-IR were measured. The absorption coefficients of silver halide crystals, deformed crystals, and fibers were measured by laser calorimetry at several different wavelengths in the near-IR and the mid-IR. The absorption coefficients of the fibers were higher than those of the deformed crystals and these were higher than those of the un-deformed crystals. We suggest that the absorption behavior is best described by a weak absorption tail. The total attenuation in fibers was measured using the cut back method.The scattering values were calculated by subtracting the absorption coefficients from the total attenuation coefficients. The scattering in the silver halide fibers was ascribed to pores of estimated size of 0.7 lm. We showed that the main contribution to the attenuation of fibers in the mid-IR range was due to scattering and suggested that reducing the scattering will dramatically improve the transmission of silver halide fibers in the mid-IR. V C 2014 AIP Publishing LLC.

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