A series of parasubstituted tetraphenylporphyrin zirconium(IV) salicylate complexes (SA/5-SSAZr(IV)RTPP, R = p-H, p-CH3, p-NO2, p-Cl, SA = salicylate, and 5-SSA = 5-sulfosalicylate) have been synthesized, and the spectral properties of free base porphyrins, their corresponding metallated, and axially ligated zirconium(IV) porphyrin compounds were compared with each other. A detailed analysis of ultraviolet-visible (UV-vis), proton nulcear magnetic resonance (1H NMR) spectroscopy, infrared (IR) spectroscopy, and elemental analysis suggested the transformation from free base porphyrins to zirconium(IV) porphyrins. The ability of the metal in this complex for extra coordination of solvent molecules was confirmed by ESI-MS spectra. Besides the fluorescence, cyclic voltammetry, and thermogravimetric studies, the complexes were also screened for antimicrobial and anticancer activities. Among all the complexes, 5-SSAZr(p-NO2TPP) shows high antibacterial activity.

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New symmetrically para-substituted tetraphenylporphyrin Tl(III) salicylate complexes, having the general formula SA/5-SSATl(III)t(4-Y)PP (Y = -H, -CH 3 , -OCH 3 ); SA = salicylates and 5-SSA = 5-sulfosalicylates, were synthesized and characterized by elemental analysis, optical absorption/emission studies, infrared spectrum, NMR studies ( 1 H, 205 Tl), thermal analysis and mass spectra; the complexes are in good consistency with experimental results. All the newly synthesized complexes exhibited good optical property, and thermogravimetric analysis (TGA) results showed their excellent thermal stability ( > 400°C). Macrocyclic complexes of Tl(III) ligate to axial ligand to form six-coordinate complex, the nature of which influences the photophysical properties of the former depending upon the spin-orbital coupling character of the axial ligand. A square-based pyramidal structure has been proposed on the basis of these studies. In addition, some of the synthesized complexes of thallium porphyrins were also screened for anti-bacterial activity. Cytotoxic activity of 5-SSATl(III)t (4-OCH 3 )PP evaluated against four human cancer cell lines exhibited strong (up to 90%) growth inhibition.

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