Background: One of the most common difficulties in the operation fatality is perforation peritonitis. The goal of this study was to identify risk factors for peptic ulcer disease (PUD) in young patients. Materials and method: In this study, 70 patients were evaluated and clinical examinations and endoscopies were performed at 8 weeks and 6 months. Place and Duration: A population‐based cohort study was conducted at the Gastroenterology department of Sharif Medical College, Lahore for one-year duration from January 2021 to December 2021. Result: Six patients died, and 4 patients were not followed up on, out of a total of 80 patients. There were 62 men and 8 women among the remaining 70 patients. The majority of the patients were between the ages of 35 and 40. After eight weeks, 34 (50%) had no infections on endoscopy, with 34 patients (48.6%) on treatment and 1 (1.4%) not on any therapies. The residual 35 patients (50%) had active ulcers and other positive endoscopic outcomes. Six months after surgery, 56 patients (80%) had no ulcers on endoscopy, with 34 on treatment and 12 without treatment. The rest 14 had some positive endoscopic findings. The study also revealed other factors linked with peptic ulcer perforation and impacting healing in the postoperative phase. Preoperative PUD symptoms, alcohol consumption, comorbidities, chronic drug consumption (NSAIDs/steroids), smoking, postoperative treatment given and H. pylori infection were all variables. Conclusion: All patients with peptic ulcer perforation should receive H2 blockers or proton pump inhibitors as a post - operative therapies, as well as an anti-Helicobacter pylori regimen. Postoperative follow-up should include routine endoscopic examinations of these patients to detect ulcer healing. Keywords: peptic ulcer disease, endoscopies, chronic drug consumption.

Iron deficiency anemia is the most prevalent anemia type and is identified by the use of blood tests for iron levels. In iron deficiency anemia, reactive thrombocytosis is a common complication. The study's primary goal is to determine if there is a relationship between platelet and iron parameters in patients with iron deficient anemia. Place and Duration: This cross-sectional research was done among patients with iron deficiency anemia in the Department of Medicine and Pathology, Sharif Medical College, Lahore for one-year duration from January 2021 to December 2021. Method: This Observational research was conducted in the Department of Medicine and Pathology order to collect information. The platelet and iron parameters of 70 iron deficiency anemia patients were determined using blood samples taken from the patients. The data was analyzed with the help of SPSS version 20. Results: Patients with iron deficiency anemia were found to have thrombocytosis in 58 (82.9 percent) of the cases. When serum iron, percentage saturation, and platelet distribution were taken into consideration (all p0.001), platelet count was shown to be adversely connected to these variables, but a positive association was found between plateletcrit and platelet count (all p<0.05). There was a negative link between serum iron and plateletcrit (p<0.001) and PDW (p<0.05), but only a positive relationship was found with TIBC, mean platelet volume (p<0.05), and platelet (all p<0.05). There was a significant negative relationship between platelet count and mean platelet volume (p<0.001). Platelet and mean platelet volume correlated positively (p<0.05), while plateletcrit and mean platelet volume correlated negatively (p<0.05). Neither a correlation nor a non-correlation between iron parameters and mean platelet volume were discovered (p>0.05). Conclusion: When it comes to patients with iron deficient anemia, thrombocytosis is more prevalent than thrombocytopenia. The most critical factors impacting platelet count are serum iron and percentage saturation. Keywords: Hemoglobin, thrombocytosis and iron deficiency anemia.