The wide spectrum of SARS-CoV-2 variants with phenotypes impacting transmission and antibody sensitivity necessitates investigation of the immune response to different spike protein versions. Here, we compare the neutralization of variants of concern, including B.1.617.2 (Delta) in sera from individuals exposed to variant infection, vaccination, or both. We demonstrate that neutralizing antibody responses are strongest against variants sharing one or more spike mutations with the immunizing exposure. We also observe that exposure to multiple spike variants increases the breadth of variant cross-neutralization. These findings contribute to understanding the relationship between exposures and antibody responses and may inform booster vaccination strategies.

This study evaluates the effect of low temperature (60, 64 and 68 °C) and different times (15 and 20 min) of cooking on physicochemical and sensory characteristics of confit cod and analyzes confit cod in a non-destructive way by means of magnetic resonance imaging (MRI) and computer vision techniques. Higher scores for acceptability and flavor in 60 °C–20 min and 64 °C–20 min samples and some physicochemical differences were found. These results allow distinguishing four groups of confit cods as a function of cooking conditions – 60 °C–15 min/68 °C–15 min/68 °C–20 min/60 °C–20 min, 64 °C–15 min, 64 °C–20 min – and proposing to cook confit cod at 60–64 °C during 20 min. Prediction by means of computational texture features from MRI gave moderate-to-good correlation (0.6–0.75) for six quality attributes and very good-to-excellent relationship (0.75–1) for other six. Thus, computational texture features seem to be appropriate to determine the quality attributes of confit cod in a non-destructive way.

A high yielding synthesis of 1,3-oxazinan-2-ones starting from 3-amino-1-propanols and ethylene\ud carbonate (EC) in the presence of catalytic amount of triazabicyclodecene (TBD) is herein reported. The formation\ud of six-membered cyclic carbonates was achieved by intermolecular cyclization reaction via double\ud BAc2 mechanism. Cyclization reactions have been carried out in neat as EC acted both as solvent and reagent.\ud Pure 1,3-oxazinan-2-ones were isolated in high yield by simple liquid-liquid extraction. Further purification\ud can be achieved by recrystallization. The reaction resulted of general application on different substrates\ud including an aryl bis(3-amino-proan-1-ol) compound

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