Background Helicobacter pylori (H. pylori) infection is the most important risk factor for gastritis and peptic ulcer. However, factors other than H. pylori are involved in its pathogenesis. In the current study, we aimed to compare the clinical manifestations and endoscopic and histopathological findings of patients with and without H. pylori infection. Methods In this cross-sectional study, 233 patients with dyspepsia, referred for endoscopy, were examined regarding the presence of H. pylori infection. During an endoscopic exam, 5 biopsy specimens were taken from the stomach. The criteria for the presence of H. pylori infection was the presence and identification of bacteria in pathology. Two groups of H. pylori-positive and H. pylori-negative patients were compared regarding their demographic, endoscopic, and pathological findings. Results Of 233 patients, 154 (66.1%) were non-smokers, 201 (86.3%) were not alcohol users, and 153 (65.7%) used tap water. The most common symptom, reported in 157 (67.4%) patients, was epigastric pain. There was a significant difference between patients with and without H. pylori infection in terms of the educational status, occupational status, family history of gastrointestinal cancer, and some gastrointestinal symptoms. Also, there was a significant relationship between the endoscopic and pathological findings of patients with H. pylori. Conclusions The results of the present study revealed that H. pylori infection was not associated with sex, alcohol consumption, or non-steroidal anti-inflammatory drug use. The role of H. pylori in the pathophysiology of peptic ulcer was clarified. Also, there was a significant difference in the endoscopic and pathological findings of patients with H. pylori.

Background: Helicobacter pylori infection is the most important risk factor for Gastritis and Peptic Ulcer. But other factors except H. pylori play roles in its pathogenesis. In current study we compare the clinical manifestation and endoscopic and histopathology findings in patients with and without H. pylori infection.Methods: In this cross-sectional study, 233 of patients with dyspepsia who referred for endoscopy were studied about presence of H. pylori infection. During endoscopy 5 biopsies were taken from each individual. The criteria for presence of H. pylori infection was the presence and recognition of bacteria in pathologic specimen which was done for all patient. These two groups of patient were compared with their demographic, background, endoscopic and pathologic findings. Results: From 233 cases, 154 (66.1%) cases were non-smoker, 201 (86.3%) cases were not alcohol user, 153 (65.7%) cases used tap water and the most common symptom was reported in 157 individual (67.4%) was epigastria pain. There was a significant relation between the number of family member, marital status and presence of H. pylori infection. Also there is a significant relation between endoscopic findings and pathologic findings in patients with H. pylori.Conclusions: the results of current studt demonstrated that H. pylori infection was not associated with sex, alcohol and NSAID drugs. According to the role of H. pylori in pathophysiology of peptic ulcer was clarified, also in this study there were a significant difference in endoscopic and pathological findings H. pylori.