In the present research, we investigate whether cultural value orientations (CVOs) and aggregate personality traits (Big-5) predict actual levels of alcohol consumption, smoking, and obesity across 50 countries using averages derived from millions of data points. Aggregate traits explained variance above and beyond CVOs in obesity (particularly neuroticism and extraversion), while CVOs explained variance beyond aggregate traits in alcohol consumption (particularly harmony and hierarchy). Smoking was not linked to aggregated traits or CVOs. We conclude that an understanding of the cultural correlates of risky health behaviors may help inform important policies and interventions for meeting international sustainable development goals.