Background: Several factors can affect the oral health-related quality of life in children. Objectives: The aim of this study was to evaluate the dental status and its relationship with the oral health-related quality of life in preschool children in Zahedan City, Iran. Methods: In this descriptive-analytical cross-sectional study, 200 preschool children (5 -6 years old) were randomly selected from different areas of Zahedan city. Dental health status of children was investigated using the decayed, missing and filled teeth (DMFT) questionnaire. Oral-health-related quality of life of the children and their parents was measured using the Farsi version of the early childhood oral health impact scale (F-ECOHIS index). Data were analyzed using SPSS version 20, statistical t-test and Pearson correlation coefficient at the significant level of 0.05.