This study evaluated the possible neuroprotective effect of Allium atroviolaceum extract (AaE)-synthesized selenium nanoparticles (SeNPs) on aluminum (Al)-induced neurotoxicity in mice, explaining the likely mechanisms. Mice were divided into five groups: G1, control; G2, AaE group that received AaE (200 mg/kg) for 4 weeks; and groups 3, 4, and 5 received AlCl3 (100 mg/kg) for 3 weeks. After that, G4 received AaE (200 mg/kg), and G5 received SeNPs-AaE (0.5 mg/kg) for another 1 week. Exposure to AlCl3 boosted oxidative damage in brain tissue as evidenced by a reduction in glutathione concentrations and other antioxidant enzymes along with increased lipid peroxidation and nitric oxide levels. There was also a rise in the concentrations of interleukin-1β, TNF-α, and cyclooxygenase-II activities. AlCl3-treated mice showed reduced brain-derived neurotrophic factor (BDNF) and dopamine levels, increased acetylcholinesterase (AChE) activity, and reduced Bcl-2, and Bax, and caspase-3 activities. Treatment with SeNPs-AaE significantly reduced markers of oxidative stress, inflammation, and apoptosis. In addition, in SeNPs-AaE-treated rats, levels of BDNF and dopamine were significantly increased along with a reduction in AChE as compared with the AlCl3 group. Therefore, our results indicate that SeNPs-AaE has a potential neuroprotective effect against Al-mediated neurotoxic effects because of its powerful antioxidant, anti-inflammatory, anti-apoptotic, and neuromodulatory activities.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.