Background: EEG is one of the most sensitive instrumental techniques for identifying sepsis-related neurological complications and a valuable tool in the ICU when clinical assessment is difficult. Aim of the Study: To detect EEG changes in neonates with evidence of sepsis. Patients and Methods: This was a prospective observational study for detecting EEG changes in cases of proven neonatal sepsis. This study was conducted at the NICU of Al Zahraa University Hospital for a period from October 2019 to March 2020. Our studied neonates were 50. This study included full-term newborns (37 to 42 weeks of gestational age) with clinical and laboratory evidence of sepsis (early and late onset). Neonatal birth asphyxia, jaundice, congenital malformations, suspected inborn error of metabolism and neonates electrolytes disturbances were excluded from the study. We record EEG changes during 20 min By an electroencephalogram (EEG) with abioelectric amplifier (Deltamed, Bourgogne), (Philips) Screen. Results: Among our studied neonates (neonates with evidence sepsis), 44.0% developed clinical seizures, 81% of the seizures group had abnormal EEG, 35.7% of No seizures group had abnormal EEG. Among our studied neonates, 56% had abnormal EEG EEG abnormalities were as follow, 26%/ had low voltage, 30% had spikes, 22% had sharp waves. Conclusion: About 35% (one third) of neonates who didn't develop clinical seizures had abnormal EEG, suggesting a poor correlation between clinical and electroencephalographic detection of seizures.