Understanding the impact of climate change on the vegetation cover in the past is crucial for predicting the future warming scenario and its consequences. The present study integrates biotic (palynological analysis) and abiotic proxy (sediment chemistry, clay mineral assemblages and grain size end member (EM) analysis) records in a chronologically constrained sedimentary sequence from the southeastern part of the Mahanadi River delta to reconstruct the hydroclimate since 2600 years. The Mahanadi delta sediments are primarily derived from felsic rock source possibly composed of granites or granulites. The dominance of herbaceous taxa, high aridity index and deposition of fine grain (EM1) sediment possibly suggest a relatively cold and dry climate in the study region during ~2600–2100 cal yr BP corresponding to the Iron Age Cold Period (IACP). Presence of diverse mangrove and tree taxa, deposition of coarser sediment (EM3) and relatively high abundance of secondary clay minerals possibly indicate high precipitation associated with the Roman Warm Period (RWP, ~2100–1800 cal yr BP). A decline in mangroves, dominance of herbaceous taxa and high deposition of fine grain (EM2) sediment from ~1800 to 1300 cal yr BP may indicate a relatively drier climate coinciding with the Dark Age Cold Period (DACP). High moisture index and an increased value of Rb/Sr during ~1300 cal yr BP may suggest a wet phase with the onset of the Medieval Climatic Anomaly (MCA) and later shifted to an arid climate during ~1100–800 cal yr BP. After ~800 cal yr BP, a sharp decline in all weathering indices and vegetation cover, dominance of illite indicates a relatively dry climate which could mark the Little Ice Age (LIA, ~800–300 cal yr BP). A small increase in the terrestrial flux, as well as the weathering indices after ~300 cal yr BP, may suggest the onset of recent warming.