*Objectives: To determine if a pharmacist assisted psychiatric clinic would improve adherence to medications and quality of life over 6 months. The primary study endpoints were the change from baseline in Medication Adherence Rating Scale (MARS), Brief Evaluation of Medication Influences and Beliefs (BEMIB), World Health Organization Quality of Life -BREF (WHOQOL-BREF) scales as well as hospitalizations and emergency room visits. Secondary endpoints included metabolic and physiologic parameters. Methods: A prospective, single-center study conducted at an outpatient psychiatric clinic. Subjects were required to attend 3 clinic visits (baseline, 3 and 6 months) with the pharmacist. Subject and medication histories were obtained at each visit. Subjects' records within the local health system were reviewed for emergency room visits and hospitalizations. Metabolic parameters were assessed at each visit. Results: Twenty-seven subjects enrolled and twenty subjects completed. Total MARS score at baseline and study end were 7.90 and 8.65, respectively. At baseline, 10 (50%) were nonadherent based on the BEMIB and 9 (45%) were nonadherent at 6 months. Statistically significant improvements were seen in 2 domains of the WHOQOL-BREF. Reductions in both ER visits and hospitalizations were achieved. There were significant improvements in total cholesterol and LDL. Conclusions: Improvements were seen in two domains of the WHOQOL-BREF -physical capacity and psychological well-being over the 6 month period. While improvements were seen in various rating scales, due to small sample sizes, these were insignificant improvements. Reductions in hospitalizations and ER visits were also seen during the study and up to 6 months post study. Statistically significant improvements were also seen in both total cholesterol and LDL. The lack of improvement in many of the study outcomes reflects Se solicitó a las personas que acudiesen a 3 visitas a la clínica con el farmacéutico (inicio, 3 y 6 meses). En cada visita se recogió las historias clínicas y medicamentosas. Se revisaron las fichas de los pacientes en el sistema local de salud para las visitas a urgencias y hospitalizaciones. En cada visita se evaluaron los parámetros metabólicos. Resultados: Se evaluó a 27 individuos y 20 completaron el estudio. Las puntuaciones del MARS al inicio y al final fueron 7,90 y 8,65, respectivamente. En el inicio, 10 (50%) eran incumplidores, basándose en el BEMIB y 9 (45%) fueron incumplidores a los 6 meses. Se encontraron mejoras estadísticamente significativas en 2 dominios del WHOQOL-BREF. Se consiguieron reducciones tanto en visitas a urgencias como hospitalizaciones. Hubo mejoras significativas en colesterol total y LDL. Conclusiones: Se encontraron mejoras en dos dominios del WHOQOL-BREF -capacidad física y bienestar psicológico durante el periodo de 6 meses. Aunque se encontraron mejora en varias escalas, debido a los pequeños tamaños de muestra, no fueron significativas. Se vieron reducciones en Lizer MH, Parnapy Jawaid SA, Marsh W, Mogi...