Global lung parenchymal glycolysis and lung parenchymal SUVmean may serve as potentially useful biomarkers to quantify lung inflammation on FDG PET/CT following thoracic radiation therapy.

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Abnormally decreased T2/T2 FLAIR signal can be seen on brain imaging of patients who are experiencing clinical or subclinical seizures and can be associated with various intracranial pathologies. We identified 29 such patients. The abnormal signal was unilateral in 75.9% of patients. It affected various lobes of the brain, but only in the anterior circulation. In 28 patients (96.6%), there was corresponding decreased signal on DWI. The ADC was normal in all cases. In 26 patients (89.7%), there was corresponding low signal on SWI/gradient recalled-echo; 44.8% of patients underwent contrast-enhanced scans, and there was no abnormal enhancement. Twenty-two (75.9%) patients had documented clinical seizures on the day of imaging. The most frequent concomitant pathology was a subdural hematoma. Electroencephalograms obtained within 24 hours of imaging were available in 65.5%. Findings of all of these electroencephalograms were abnormal, and these electroencephalogram changes were either localized to the area of the abnormal MR imaging signal (where the signal was unilateral) or were bilateral (where the MR imaging changes were bilateral). In summary, decreased white matter T2/T2 FLAIR signal changes can be seen in patients with remarkably similar clinical findings (particularly seizures). These changes are often correlated with abnormal electroencephalogram activity localized to the involved lobes.ABBREVIATIONS: EEG 4 electroencephalogram; GRE 4 gradient recalled-echo M uch has been published on the abnormal MR imaging appearances of the brain in patients experiencing acute seizures. 1 These articles have mainly focused on the more common descriptions of such changes, namely diffusion restriction and T2 hyperintensity in the gray matter and/or subcortical white matter. 2,3 Transient cortical swelling or parenchymal enhancement or both have also been described.Less attention has been paid to decreased signal in the subcortical white matter on T2-weighted and T2-weighted FLAIR sequences. These changes have been described in various conditions such as intracranial hypotension, 4 head injury, 5 encephalitis, meningitis, leptomeningeal disease, 6 diffuse axonal injury, and cortical ischemia 7 and in patients with seizures. 8 We report a series of 29 patients with abnormally decreased T2 FLAIR signal in the subcortical white matter. We describe their imaging appearances, clinical and EEG findings, and follow-up.