The scope of this work is the simulation of a semiconductor manufacturing model in Arena® software and subsequent optimization and sensitivity analysis of this model. The process is considered extremely complex given the amount of steps, machinery, parameters, and highly reentrant characteristics, which makes it difficult to reach stability of production process. The production model used was the Intel Five-Machine Six-Step Mini-fab developed by Karl Kempf (1994). It was programmed in Arena® and optimized by OptQuest®, an add-on. We concluded that variation in the number of machines and operators reflects on cycle time only if there is an increase of one unit of resource more than obtained in the optimization. As a result, we highlighted the scenario where a reduction in cycle time stood out, in which one extra unit was added in the second machine group, representing a 7.41% reduction in cycle time.