Background: Previous studies have demonstrated inadequate patient knowledge about basic aspects of warfarin therapy, leading to nonadherence. Patients may not receive adequate education because of time constraints, lack of availability of resources, or other patient variables beyond the control of healthcare providers, such as poor patient recall. Objective: We explored the impact of a specifically developed mobile application (mApp)-Coagulation and Anticoagulant Therapy and Awareness (CATA)-on improving the knowledge and anticoagulation satisfaction of patients receiving warfarin therapy. Setting: Two medical centers' anticoagulant clinics (ACCs) in Riyadh, Saudi Arabia. Method: This was a prospective multi-center study with a single-arm pre-and post-test design; 45 patients (32 women; Mage = 45.82 ± 12.8 years) were enrolled. Main outcome measure: Patients' knowledge and anticoagulation satisfaction were evaluated at baseline and after a post pharmacist-led mHealth App educational intervention. Results: The CATA intervention had a significant impact on knowledge improvement; however, no significant changes were observed in satisfaction. Conclusions: The newly developed CATA mApp has vast potential in improving patients' knowledge; however, further exploration of factors behind the nonsignificant change in patients' anticoagulation satisfaction requires investigation in long-term prospective studies with more frequent pharmacists' interventions in ACCs.