Despite the rich vascularization of the penis and its close proximity to other pelvic organs, cutaneous manifestations of metastatic disease to the penis are an uncommon occurrence. Penile lesions suspected for malignancy should alert clinicians to differentiate between primary and secondary tumors. While the majority of metastatic malignancies arise from the genitourinary tract, we present a unique case report of a 51-year-old male with penile metastasis of primary rectal adenocarcinoma. A thorough diagnostic evaluation was performed including imaging studies, colonoscopy, as well as penile biopsies with associated immunohistochemistry panel. The patient was diagnosed with penile metastases secondary to invasive rectal adenocarcinoma. Due to the aggressive nature of the patient’s presentation, systemic chemotherapy was initiated for palliative measures as the patient declined any radical surgical intervention.

2412] Figure 1. Biopsy of bronchial mucosa showing dense infiltration of eosinophils beneath the bronchial epithelium (greater than 50 per high power field). The granular pink cells are the eosinophils, largely on the left-hand side of the image (400X magnification, H&E stain).

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