This paper identifies and investigates the distribution patterns, physical properties and cultural associations of the four types of rock art found on Uneapa Island, West New Britain, Papua New Guinea. It generates a series of hypotheses relating to the production and consumption of cupules, three‐dimensional, curvilinear and rectilinear rock art, and how this may have changed through time.
BackgroundTo improve convenience to patients, there have been advances in the operation of nebulizers, resulting in fast treatment times and less drug lost to the environment. However, limited attention has been paid to the effects of these developments on the delivered dose (DD) and respirable delivered dose (RDD). Published pharmacopoeia and ISO testing guidelines for adult-use testing utilize a single breathing pattern, which may not be sufficient to enable effective comparisons between the devices.Materials and methodsThe DD of 5 mg of salbutamol sulfate into adult breathing patterns with inhalation:exhalation (I:E) ratios between 1:1 and 1:4 was determined. Droplet size was determined by laser diffraction and RDD calculated. Nine different nebulizer brands with different modes of operation (conventional, venturi, breath-enhanced, mesh, and breath-activated) were tested.ResultsBetween the non-breath-activated nebulizers, a 2.5-fold difference in DD (~750–1,900 µg salbutamol) was found; with RDD, there was a more than fourfold difference (~210–980 µg). With increasing time spent on exhalation, there were progressive reductions in DD and RDD, with the RDD at an I:E ratio of 1:4 being as little as 40% of the dose with the 1:1 I:E ratio. The DD and RDD from the breath-activated mesh nebulizer were independent of the I:E ratio, and for the breath-activated jet nebulizer, there was less than 20% change in RDD between the I:E ratios of 1:1 and 1:4.ConclusionComparing nebulizers using the I:E ratio recommended in the guidelines does not predict relative performance between the devices at other ratios. There was significant variance in DD or RDD between different brands of non-breath-activated nebulizer. In future, consideration should be given to revision of the test protocols included in the guidelines, to reflect more accurately the potential therapeutic dose that is delivered to a realistic spectrum of breathing patterns.
Although on face value, museum collections are largely perceived as static entities hidden away in storerooms or trapped behind glass cases, new research shows that over time and across space interactions between objects and a wide range of people have generated a complex assemblage of material and social networks. Based on a broad collection of source materials, studies examining the people who made, sold, traded, studied, catalogued, exhibited and connected with objects reveal a dynamic set of material and social agencies that have been instrumental in creating, shaping and reworking museum collections. By integrating and reworking theories about agency and materiality and by drawing on insights from Actor-Network Theory, contributors to this volume have uncovered new ways to think about relationships formed between objects and individuals and among diverse groups spread across the globe. The research also demonstrates that ethnographic collections continue to play important roles in supporting and reworking national identities as well as to challenge these through ongoing negotiations and sharing of ideas among both the guardians of these objects and their creator communities. These insights have important implications for designing curatorial practices in the future.
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