Objective: To determine the effect of magnesium, calcium, and potassium levels on calf muscle cramps in third-trimester pregnant women at Dr. Zainoel Abidin Banda Aceh. Methods: This research is an observational analytic study with a case-control method by taking samples using a total sampling technique. The research sample was third-trimester pregnant women (28-40 weeks of gestation) who were treated in the maternity ward for the period September to December 2020. Results: A total of 263 samples were involved in this study where 105 patients (40%) were obese, 229 patients (87%) were housewives, 161 patients (61%) did not experience muscle cramps and samples had magnesium levels below normal as much as 82 people, calcium levels below normal as many as 127 people and potassium levels below normal as many as 2 people. The mean levels of magnesium, calcium, and potassium were 1.8 mg/dL, 8.69 mg/dL, and 4.25 mmol/L, respectively. The results of this study are magnesium levels affect muscle cramps in pregnant women (p-value=0.000), while calcium levels (p-value=0.373) and potassium (p-value=0.062) do not affect muscle cramps in pregnant women. Conclusion: There is a significant effect between magnesium levels on the incidence of calf muscle cramps in third-trimester pregnant women, while calcium and potassium levels do not affect them. Keywords: Muscle Cramps, Magnesium, Calcium, Potassium.

Objective: To assess correlation of High sensitivity C-Reactive Protein (Hs-CRP), erythrocyte sedimentation rate (ESR), progesterone and estradiol levels in the first trimester threatened abortion incidence in Dr. Zainoel Abidin Hospital, Banda Aceh.Methods: Case control design used in this study divided threatened abortion into a case group and normal pregnancy into a control group with a total of 20 subjects for each group. This research was conducted in the Emergency Room and Obstetric Ward of Dr. Zainoel Abidin hospital Banda Aceh in 2019. Eta correlation test was conducted to find out the link between variables towards threatened abortion with 95% confidence level followed by the Receiver Operating Curve (ROC) analysis to find out the cut off points.Results: Progesterone levels (14.76 ng/mL), estradiol (427.61 pg/mL), Hs-CRP (2.57 mg/L) and ESR (28.75 mm/hour) case group were lower compared to the control group. Incidence of threatened abortion correlates to progesterone and estradiol with the correlation strength respectively -0.838 and -0.416.Conclusion: Progesterone and estradiol correlate negatively with first-trimester abortion incidence. Evaluation of these two hormones levels is useful for diagnostic purposes and screening of threatened abortion with a cut point of progesterone 23.03 ng/mL and estradiol 468.8 pg/mL.Keywords: C-Reactive Protein, erythrocyte sedimentation rate, estradiol, progesterone, threatened abortion   Abstrak Tujuan: Penelitian ini bertujuan untuk menilai korelasi antara kadar High sensitivity C-Reactive Protein (Hs-CRP), Laju Endap Darah (LED), progesteron dan estradiol terhadap kejadian abortus imminens pada trimester pertama di RSUD Dr. Zainoel Abidin Banda Aceh. Metode: Desain kasus kontrol digunakan dalam penelitian ini dimana kejadian abortus imminens menjadi kelompok kasus dan kehamilan normal menjadi kelompok kontrol dengan jumlah masing-masing kelompok sebanyak 20 sampel. Penelitian ini dilakukan di Instalasi Gawat Darurat dan ruang rawat Obstetri Rumah Sakit Umum Dr. Zainoel Abidin (RSUDZA) Banda Aceh pada tahun 2019. Uji korelasi Eta digunakan untuk mengetahui korelasi antar variabel terhadap abortus imminens dengan tingkat kepercayaan 95% dilanjutkan dengan analisis Receive Operating Curve (ROC) untuk menentukan titik potong. Hasil: Kadar progesteron (14,76 ng/mL), estradiol (427,61 pg/mL), Hs-CRP (2,57 mg/L) dan LED (28,75 mm/jam) kelompok kasus lebih rendah dibandingkan kelompok kontrol. Kejadian abortus imminens berkorelasi terhadap progesteron dan estradiol dengan kekuatan korelasi (R) secara berurutan -0,838 dan -0,416. Kesimpulan: Progesteron dan estradiol berkorelasi negatif terhadap kejadian abortus imminens pada trimester pertama kehamilan. Evaluasi kadar kedua hormon tersebut bermanfaat untuk kepentingan diagnostik dan penapisan abortus imminens dengan titik potong progesteron 23,03 ng/mL dan estradiol 468,8 pg/mL. Kata kunci: abortus imminent, C-Reactive Protein, estradiol, laju endap darah, progesteron

Curcuminoids are widely known to have biological activities such as antioxidant, anti-inflammatory, antiarthritis and anticancer. Even the use of curcumin has reached the first stage of clinical trials in overcoming a number of cancers. Interestingly, a number of curcumin metabolites also have anticancer effects that are equivalent to or even better than curcumin through a series of preclinical tests, but the description of their molecular interactions is still very limited so that in silico evidence is needed. QSAR and Molecular Docking were used as test methods using MOE 2008 software version 10. The research material was a 3D structure of curcumin derivative for QSAR analysis and curcumin metabolites for molecular docking analysis. Receptors downloaded from www.rscb.org include the 3D structure of MAPK, Akt, MDM2, NFkB, Cox-2, and VEGF, while the 3D structure of “human tubulin -1” was obtained from modeling. The QSAR results show that the anticancer activity of curcumin metabolites is stronger than curcumin except for dihydrocurcumin. The docking results also show that curcumin metabolites have the same affinity, even stronger than curcumin and control receptors with docking scores between 10-16kcal/mol. Curcumin and its metabolites were also able to increase the affinity of paclitaxel to the "human tubulin -1" receptor model as the target of paclitaxel's action which was characterized by an increase in the post-combination paclitaxel decking score. This study shows that curcumin is very suitable to be used as an anticancer because not only curcumin, but its metabolites also show better anticancer abilities.