Highlights Imaging the reorganization of pain neural circuitry within 8 days of chemotherapy. Using rat model of neuropathy with multimodal MRI. Showing loss of anticorrelation between prefrontal cortex and PAG. Identifying the interaction between periaqueductal gray and brainstem raphe.

The Tzanck smear was introduced in the 1950s and has been used for the diagnosis of erosive, vesiculobullous, tumoral, and granulomatous diseases. The Tzanck smear is rapid, easy to perform, and relatively inexpensive. Results from this diagnostic test can be obtained at the bedside, often within several minutes. Tzanck smears have high diagnostic reliability for erosive/vesiculobullous and granulomatous lesions. For some lesions, the sensitivity of Tzanck smears can exceed 80% up to 90% depending on the expertise of the user. However, for more challenging diagnoses, Tzanck smear should be used in conjunction with more advanced techniques to ensure an accurate clinical diagnosis. This article reviews the background, indications, construct, and applications of the Tzanck smear to highlight this commonly used diagnostic tool in dermatology.

Numbers and roles of advanced practice providers (APPs) in dermatology have expanded tremendously over the last five decades. Although the imbalance between demand for dermatology services and available dermatologists may contribute to this increase, little research has been done to examine the evolving roles of APPs and ongoing trends as represented by scientific publications. To analyze publication trends, key topics, and perceptions related to APPs, the PubMed database was searched for all articles related to APPs in dermatology published from 1973 to 2018. The number of publications, citation counts, and favorability toward APPs were assessed and scored by two independent evaluators. Increased prevalence of APPs in dermatology mirrors a substantial increase in the total number of APP-related publications, whereas the proportion of publications showing positive perceptions of APPs was found to decrease over time. Top-cited articles focused on dermatology workforce shortages, roles of APPs, and comparisons of efficacy among providers. We hope this study will offer insight to all healthcare providers with considerations regarding the evolving roles of APPs in dermatology.