Ischemic stroke is a medical emergency, which represents a sudden and catastrophic event, carrying a significant risk of death. Emergency nurses are in the forefront of providing interventions to preserve ischemic cerebral tissue and prevent further neurological deficits. The up to date knowledge and awareness of evidence based management of stroke can significantly reduce the morbidity and mortality from stroke. So it is important to assess emergency nurse's knowledge about evidence-based nursing practice of ischemic stroke patients as this knowledge has a direct effect on nurse's practice affecting the general care given for patients. Identifying insufficient knowledge may foster an opportunity for the continuing education of emergency department nurses. Aim of the study: The aim of this study was to assess emergency nurse's knowledge about evidencebased nursing practice of ischemic stroke patients. Materials and methods: This study was carried out in Emergency Department, Emergency Hospital, Mansoura University. Subjects of the study comprised 50 nurse in the emergency department who have experience from two years and more and involved in providing care for ischemic stroke patients in the above mentioned setting were included in the study. Results: The results of the study showed that more than three quarters of emergency nurses (78%) had unsatisfactory knowledge about evidence-based nursing practice of ischemic stroke patients. Additionally, there were statistically significant relation between nurses' total knowledge about evidence-based nursing practice of ischemic stroke patients and age, level of education and job title, years of experience and attending training programs, conferences or workshops about nursing care of ischemic stroke patients. Conclusion: it is important to provide in-service training programs for emergency nurses about care of ischemic stroke patients in order to optimize patient outcomes