DNA plasmids and recombinant adenovirus serotype-5 (rAd5) vectors are being studied in human clinical trials as HIV-1 vaccine candidates. Each elicits robust T-cell responses and modest antibody levels. Since protein immunization alone elicits antibody but not CD8 T-cell responses, we studied protein boosting of DNA and rAd5 HIV-1 vaccine vectors. A single Env protein immunization provided a marked boost in antibody titer in guinea pigs primed with either DNA or rAd5 vaccines, and the resulting antibody binding and neutralization levels were similar to those attained after thee sequential protein immunizations. Since both T-cell immunity and neutralizing antibodies are thought to be required for protection against HIV-1, it may be possible to establish a balanced T-cell and antibody response with appropriate vectored vaccines and improve the neutralizing antibody titer with protein boosting.

No abstract

reminded that many who are "seeking God in the crucible of ministry" are attempting to live it alone. As Barton emphasizes, those who came alongside Moses helped shape his calling and the realization of his ministry. At midpoint in the book, Barton invites us to "the new normal." Barton writes, "In a culture of spiritual transformation it becomes normative to take time for breathing, for prayer, for quiet at the beginning of important meetings and at important junctures during any meeting. It becomes normal for staff people to have a solitude day each month. .. to take vacation time and to be completely unplugged. .. to take Sabbath" (132). The remainder of the book gives us permission to consider new ways of thinking, living and creating practices geared towards a "new normal" within our soul and within our ways of leading. It moves us from the place of loneliness in leadership to aloneness with God. It sets before us the art of spiritual formation rather than the tasks of ministry. It reveals ways of being in community and allowing our doing to flow out of our being (179). The words invite us to move from isolation in leadership to implementing "best practices" of living within a leadership community. My one disappointment in writing this review is that in light of reality we truly need this book. I found myself being concerned-perhaps grieving-at the overall state of the souls of Christian leaders. Perhaps we have bumped into our own fears, arrogance, and pride long enough to heed Haley Barton's reminder that it is often the good works of ministry that lead us to these chaotic ways of living. "We have given ourselves to patterns that no longer serve us" (53). We have lost sight of who we are in relationship to God. Strengthening the Soul of Your Leadership is a book which beckons us to rest, retreat, and make space for healing and renewal. Barton has written a book which could serve as a prescription for people in ministry who have come to the end of themselves. I recommend this book for leaders who have experienced a glance towards the dark night of the soul but have found themselves working harder, trusting less and growing weary in order to avoid the transforming work of the soul. My prayer is that we can allow the words of this book and the meditations of our hearts to be pleasing to the Lover of our souls.