Objective: Schizophrenia is an acute mental disorder with unde ned etiology. The high heritability of the disease hints that several genetic variants and polymorphisms contribute to schizophrenia symptoms and severity. Former molecular evidence shed a light on the association of serotonergic pathway genetic polymorphisms with schizophrenia. Here, we investigated the association between schizophrenia and two SNPs from one haplotype block, which lies within 5-hydroxytryptamine receptor 2A(5-HTR2A) in the Iranian population.Material and methods: Blood samples were collected from one-hundred and fty-two patients diagnosed with schizophrenia and one-hundred and fty-eight age and sex matched healthy control. Participants were genotyped for rs6311 and rs6313 using PCR-RFLP. R programming language and Haploview software respectively were leveraged for statistical and haplotype inference.Results: The results signi ed that there was no signi cant association between rs6313 and schizophrenia. However, rs6311 T allele independently and in a rs6311-rs6313 haplotype signi cantly associated with schizophrenia. Also, the general linear model con rmed the potential predictor role of rs6311 for schizophrenia. Moreover, the C allele of rs6313 demonstrated more frequency among females compared to males.Conclusion: This study elucidated the association of rs6311 and rs6311-rs6313 haplotype with schizophrenia in the Iranian population and also suggested a potential schizophrenia risk predictor role for rs6311.

Objective: Schizophrenia is an acute mental disorder with undefined etiology. The high heritability of the disease hints that several genetic variants and polymorphisms contribute to schizophrenia symptoms and severity. Former molecular evidence shed a light on the association of serotonergic pathway genetic polymorphisms with schizophrenia. Here, we investigated the association between schizophrenia and two SNPs from one haplotype block, which lies within 5-hydroxytryptamine receptor 2A(5-HTR2A) in the Iranian population. Material and methods: Blood samples were collected from one-hundred and fifty-two patients diagnosed with schizophrenia and one-hundred and fifty-eight age and sex matched healthy control. Participants were genotyped for rs6311 and rs6313 using PCR-RFLP. R programming language and Haploview software respectively were leveraged for statistical and haplotype inference. Results: The results signified that there was no significant association between rs6313 and schizophrenia. However, rs6311 T allele independently and in a rs6311-rs6313 haplotype significantly associated with schizophrenia. Also, the general linear model confirmed the potential predictor role of rs6311 for schizophrenia. Moreover, the C allele of rs6313 demonstrated more frequency among females compared to males. Conclusion: This study elucidated the association of rs6311 and rs6311-rs6313 haplotype with schizophrenia in the Iranian population and also suggested a potential schizophrenia risk predictor role for rs6311.