No abstract

Cytokine release syndrome (CRS) is known to be associated with severe coronavirus disease 2019 (COVID‐19). Multiple anti‐inflammatory therapies such as tocilizumab, corticosteroids, intravenous immunoglobulin (IVIG), and haemoadsorption or haemoperfusion have been used to combat this life‐threatening condition. However, immunocompromised hosts are often omitted from research studies, and knowledge on the clinical efficacy of these therapies in immunocompromised patients is therefore limited. We report two cases of immunocompromised patients with severe COVID‐19‐related CRS requiring mechanical ventilation who were treated with multimodality treatment consisting of tocilizumab, IVIG, and haemoperfusion. Within 48 h, both patients showed clinical improvement with PaO 2 :FiO 2 ratio and haemodynamic stability. Both survived to discharge. There were no adverse events following these therapies. In conclusion, combined therapeutic modalities, possibly tailored to individual inflammatory profiles, are promising treatment for severe COVID‐19 infection in the immunocompromised host. Timely administration of adjunctive therapies that alleviate overwhelming inflammation may provide the best outcome.

This study aimed to explore the relationship between daily self-reported health symptoms and mental health among respiratory patients during a high-pollution period in Thailand. A cross-sectional study was conducted at the pulmonary clinic of King Chulalongkorn Memorial Hospital in Bangkok, Thailand in February 2022. Patients with respiratory diseases were enrolled and asked to self-evaluate their health via ChulaAir mobile application. Daily respiratory symptoms were assessed using a checklist for a month. The DASS21 questionnaire was used to identify depression, anxiety, and stress at the end of the month. Binary logistic regression was performed to find the associations. A total of 98 patients participated in the study, and the prevalence of depression, anxiety, and stress was 30.6%, 28.6%, and 26.5%, respectively. Cough and Phlegm were the most common health symptoms during the high-pollution period. An increase in the number of days with self-reported sore eyes was associated with depression (AOR=1.307; p=0.001), anxiety (AOR=1.261; p=0.001), and stress (AOR=1.178; p=0.001). Health symptoms are related to the presence of depression, anxiety, and stress during the high-pollution period. For individuals with respiratory symptoms, measures are required to alleviate mental health problems.